TITLE

Bone marrow changes related to disuse

AUTHOR(S)
Nardo, Lorenzo; Sandman, David N.; Virayavanich, Warapat; Zhang, Linlin; Souza, Richard B.; Steinbach, Lynne; Guindani, Michele; Link, Thomas M.
PUB. DATE
December 2013
SOURCE
European Radiology;Dec2013, Vol. 23 Issue 12, p3422
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To evaluate bone marrow changes on knee magnetic resonance imaging (MRI) in patients with 3- to 6-week-long period of unloading. Methods: MRI knee examinations were performed in 30 patients (14 men, 16 women; aged 20–53 years) at baseline and 5–10 weeks after immobilisation of the ipsilateral lower extremity; subsets of patients were examined at additional time-points. Ten volunteers (4 men, 6 women; aged 20–50 years) were studied as control cohort at two time-points. Bone marrow signal abnormalities were analysed according to: (1) severity, (2) signal alteration relative to hyaline cartilage, (3) morphology, (4) increased vascularity in the knee joint and (5) T1-signal alteration. Spearman’s rank correlation test (SRC) and Kendall’s tau (KT) were used to compare individual scores. Results: All 30 patients presented abnormal bone marrow findings after unloading, which reached a peak at 10–25 weeks ( P <0.001). These findings decreased within 1 year ( P < 0.001). High scores of severity were associated with confluent and patchy patterns of bone marrow (SCR = 0.923, P < 0.001 and KT = 0.877, P <0.001). Conclusions: Signal abnormalities of the bone marrow related to unloading are consistent findings and most prominent 10–25 weeks following immobilisation when both confluent and patchy hyperintense patterns are present. Key Points: • Disuse is associated with hyperintense MRI signal alteration on fluid- sensitive sequence. • Disuse findings are more prominent at the patella and femoral epiphyses. • Disuse MRI findings appear to be characterised by a specific chronological pattern.
ACCESSION #
91928917

 

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