Computed diffusion-weighted imaging using 3-T magnetic resonance imaging for prostate cancer diagnosis

Ueno, Yoshiko; Takahashi, Satoru; Kitajima, Kazuhiro; Kimura, Tokunori; Aoki, Ikuo; Kawakami, Fumi; Miyake, Hideaki; Ohno, Yoshiharu; Sugimura, Kazuro
December 2013
European Radiology;Dec2013, Vol. 23 Issue 12, p3509
Academic Journal
Objective: To assess the efficacy of computed diffusion-weighted images (cDWIs) of b = 2000 s/mm 2 (cDWI 2000) generated from DWIs of b = 0 and 1000 for prostate cancer (PCa) diagnosis in comparison with that of measured original DWIs of b = 1000 (mDWI 1000) and b = 2000(mDWI 2000) using 3-T MRI. Methods: Eighty patients who underwent a preoperative MRI examination, including T2WI and DWI (b = 0, 1000, 2000 s/mm 2), were enrolled in this study. Four combinations of images, protocol A (T2WI alone), B (T2WI + mDWI 1000), C (T2WI + mDWI 2000) and D (T2WI + cDWI 2000), were assessed for their diagnostic capability. Areas under the receiver operating characteristic curve (Az) and diagnostic performance were evaluated, as well as contrast ratios (CR) between cancerous and non-cancerous lesions for each DWI. Results: The highest CR was obtained with cDWI 2000 (0.29 ± 0.16). Sensitivity, specificity, accuracy, and Az of the protocols were: A: 66.3 %, 59.4 %, 63.0 %, 0.67; B: 82.6 %, 62.0 %, 72.5 %, 0.80; C: 84.1 %, 66.5 %, 75.5 %, 0.86; D: 83.2 %, 70.0 %, 76.6 %, and 0.84, respectively The specificities and accuracies of protocol C and D were significantly higher than those of protocol B ( P < 0.05). Conclusion: cDWI 2000 appears to be more effective than mDWI 1000, and at least as effective as mDWI 2000 for PCa diagnosis. Key Points: • Computed diffusion-weighted MRI with over b1000s/mm2is useful for prostate cancer detection.• Computed DWI produces any b-value images with two different b-value images.• DWI with computed b2000s/mm2is as valuable as DWI with measured b2000 s/mm2.


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