No CAG repeat expansion of polymerase gamma is associated with male infertility in Tamil Nadu, South India

Poongothai, J.
September 2013
Indian Journal of Human Genetics;Jul-Sep2013, Vol. 19 Issue 3, p320
Academic Journal
Mitochondria contains a single deoxyribonucleic acid (DNA) polymerase, polymerase gamma (POLG) mapped to long arm of chromosome 15 (15q25), responsible for replication and repair of mitochondrial DNA. Exon 1 of the human POLG contains CAG trinucleotide repeat, which codes for polyglutamate. Ten copies of CAG repeat were found to be uniformly high (0.88) in different ethnic groups and considered as the common allele, whereas the mutant alleles (not -10/not -10 CAG repeats) were found to be associated with oligospermia/oligoasthenospermia in male infertility. Recent data suggested the implication of POLG CAG repeat expansion in infertility, but are debated. The aim of our study was to explore whether the not -10/not -10 variant is associated with spermatogenic failure. As few study on Indian population have been conducted so far to support this view, we investigated the distribution of the POLG CAG repeats in 61 infertile men and 60 normozoospermic control Indian men of Tamil Nadu, from the same ethnic background. This analysis interestingly revealed that the homozygous wild type genotype (10/- 10) was common in infertile men (77% - 47/61) and in normozoospermic control men (71.7% - 43/60). Our study failed to confirm any influence of the POLG gene polymorphism on the efficiency of the spermatogenesis.


Related Articles

  • Can sperm count increase in six to eight weeks? Sah, Purushottam // Internet Journal of Endocrinology;2010, Vol. 6 Issue 1, p1 

    Medical therapy for oligospermia is usually given for a minimum period of three months, so that it covers a complete spermatogenic cycle. One experimental study shows that spermatogenic cycles may be shorter, about sixty days, in men. Here clinical data of five oligospermic men are presented to...

  • Variant in the Promoter of PACRG Correlates with Azoospermia.  // Fertility Weekly;7/1/2010, p11 

    The article presents a study on the genetic abnormality in men with impaired spermatogenesis in Australia. It states that abnormality results to male infertility found on men that has azoospermia or severe oligospermia. It mentions that examination of Parkin co-regulated gene (PACRG) was...

  • The frequency of Yq microdeletion in azoospermic and oligospermic Iranian infertile men. Zaimy, Mohammad Ali; Mehdi Kalantar, Seyyed; Hasan Sheikhha, Mohammad; Jahaninejad, Tahere; Pashaiefar, Hossein; Ghasemzade, Jalal; Zahraei, Mahnaz // Iranian Journal of Reproductive Medicine;Jun2013, Vol. 11 Issue 6, p453 

    Background: About 15% of couples have infertility problems which 40% of them are related to the male factors. Genetic factors are candidate for about 10% of male infertility conditions. Among these, AZFa, AZFb, AZFc and AZFd regions on the Yq are considered most important for spermatogenesis....

  • Genetic Risk of Azoospermia Factor (AZF) Microdeletions in Idiopathic Cases of Azoospermia and Oligozoospermia in Central Indian Population. AMBULKAR, PRAFULLA S.; SIGH, RAMJI; REDDY, M. V. R.; VARMA, POONAM S.; GUPTA, DILIP O.; SHENDE, MORESHWAR R.; PAL, ASOKE K. // Journal of Clinical & Diagnostic Research;Mar2014, Vol. 8 Issue 3, p88 

    Background: Genetic factors cause about 15% of male infertility. Azoospermia factors (AZFa, AZFb, and AZFc) present on Yq are most important for spermatogenesis. We have made an attempt to evaluate the frequencies of microdeletions of AZFa, AZFb, AZFc in idiopathic cases of azoospermia and...

  • Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia.  // Current Medical Literature: Urology;2008, Vol. 14 Issue 3, p72 

    The article discusses research on the effect of microsurgical inguinal varicocele ligation on patients with unobstructive azoospermia and severe oligospermia. It references a study by T. Ishikawa et al, published in the volume 101 issue of "British Journal of Urology (BJU) International." The...

  • Significant Improvement in Sperm Parameters could Improve Pregnancy Rates. Smit, Marji // Fertility Weekly;6/3/2013, p10 

    The article focuses on the study by Marij Smit and colleagues on the influence of sperm chromatin structure and use of varicocelectomy on pregnancy rates. It states that the study included a total of 49 men with a one-year or longer history of palpable varicocele, infertility, and oligospermia....

  • Incidental deviation of short and long CAG repeats in the androgen receptor gene for Japanese male infertility. Nakabayashi, Akira; Sueoka, Kou; Matsuda, Noriko; Asada, Hironori; Tanigaki, Reiko; Sato, Kenji; Tajimai, Hiroto; Ogata, Tsutomu; Kuji, Naoaki; Yoshimura, Yasunori // Reproductive Medicine & Biology;Dec2003, Vol. 2 Issue 4, p145 

    The present study investigated whether the CAG repeat length in exon 1 of the androgen receptor gene on the X chromosome is associated with male infertility. The CAG repeat length between the two groups of 143 idiopathic infertile Japanese men with severe oligozoospermia or non-obstructive...

  • Transmission of Y chromosomal microdeletions from father to son through intracytoplasmic sperm injection. Komori, S.; Kato, H.; Kobayashi, S.; Koyama, K.; Isojima, S. // Journal of Human Genetics;2002, Vol. 47 Issue 9, p465 

    We conducted chromosomal analysis of three male infants fathered by severe oligozoospermic males with Y chromosomal microdeletions through intracytoplasmic sperm injection (ICSI). Two of the infants had the same Y chromosomal microdeletions as their fathers. The third infant also had a Y...

  • Association with Polymorphisms of the GRTH Gene.  // Fertility Weekly;4/3/2006, p9 

    The article reports on research conducted in China that a link exists between single nucleotide polymorphisms of the gonadotrophin-regulated testicular helicase gene and impaired spermatogenesis, as published in the 2006 issue of the Human Reproduction journal. The subjects were 119 infertile...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics