TITLE

ANALGESIC ACTIVITIES OF THE AQUEOUS EXTRACT OF Ekebergia senegalensis A. JUSS STEM BARK IN ALBINO RATS

AUTHOR(S)
William, A.; Ngulde, S. I.; Tijjani, M. B.; Malgwi, B. U.; Sandabe, U. K.
PUB. DATE
April 2013
SOURCE
Continental Journal of Pharmacology & Toxicology Research;2013, Vol. 6 Issue 1, p17
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The study on the analgesic activities of aqueous extract of Ekebergia senegalensis A. Juss stem bark in albino rats was carried out. Rats were administered doses of 100 and 200 mg/kg intraperitoneally of the aqueous extract of Ekebergia senegalensis stem bark and a standard drug (pentazocine 10 mg/kg), and were subjected to hot plate and tail immersion tests maintained at a constant temperature of 50° ± 1°C. Latency to response was taken at 0, 15, 30, 60 and 90 mins after extract administration. The extract dose dependently produced significantly (p<0.05) analgesic activities in rats, in the both methods tested. The response was comparable to that of pentazocine in the hot plate method but higher than pentazocine in the tail immersion method. It was concluded that aqueous extract of Ekebergia senegalensis A. Juss stem bark have analgesic activity in albino rats.
ACCESSION #
91893031

 

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