TITLE

A strategy for enhancing the engraftment of human hematopoietic stem cells in NOD/SCID mice

AUTHOR(S)
Lee, Soo Hyun; Kim, Dae Seong; Lee, Myoung Woo; Noh, Yoo Hun; Jang, In Keun; Kim, Dong Hyun; Yang, Heung-Mo; Kim, Sung-Joo; Choi, Soo Jin; Oh, Wonil; Yang, Yoon Sun; Chueh, Hee Won; Son, Meong Hi; Jung, Hye Lim; Yoo, Keon Hee; Sung, Ki Woong; Koo, Hong Hoe
PUB. DATE
December 2013
SOURCE
Annals of Hematology;Dec2013, Vol. 92 Issue 12, p1595
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To overcome the limitations of allogeneic hematopoietic stem cell transplantation (HSCT), we conducted a study to identify a strategy for enhancing hematopoietic stem cell (HSC) engraftment during HSCT. Co-transplantation experiments with mesenchymal stem cells (MSCs) derived from adult human tissues including bone marrow (BM), adipose tissue (AT), and umbilical cord blood (CB) were conducted. We showed that AT-MSCs and CB-MSCs enhanced the engraftment of HSCs as effectively as BM-MSCs in NOD/SCID mice, suggesting that AT-MSCs and CB-MSCs can be used as alternative stem cell sources for enhancing the engraftment and homing of HSCs. CB-MSCs derived from different donors showed different degrees of efficacy in enhancing the engraftment of HSCs. The most effective CB-MSCs showed higher proliferation rates and secreted more MCP-1, RANTES, EGF, and VEGF. Our results suggest that AT-MSCs and CB-MSCs could be alternative stem cell sources for co-transplantation in HSCT. Furthermore, in terms of MSCs’ heterogeneity, characteristics of each population of MSCs are considerable factors for selecting MSCs suitable for co-transplantation with HSC.
ACCESSION #
91859214

 

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