TITLE

FAST DISSOLVING ORAL FILMS: A NOVEL DRUG DELIVERY SYSTEM FOR DICLOFENAC

AUTHOR(S)
Kumar, S. Naveen; Agilandeswari, D.; Sabitha, P.; Prathyusha, A.; Yathiraju, K.; Chandy, Vineeth
PUB. DATE
January 2013
SOURCE
Pharma Science Monitor;Jan2013, Vol. 4 Issue 1, p3649
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Fast Dissolving Films (FSF's) are the most advanced form of oral solid dosage form due to more flexibility and comfort. It improves the efficacy of the API's by dissolving within a minute in oral cavity after the contact with less saliva as compared to Fast Dissolving Tablets (FDT's), without chewing and no need of water for administration. In the present study fast dissolving film of Diclofenac sodium was prepared by solvent casting method using sodium alginate as film forming polymer and kollidon as a superdisintegrant. The prepared films were evaluated for their morphology, thickness, folding endurance, drug content, in-vitro disintegration and dissolution studies. The microphotographs of SEM indicated that a very homogenous and smooth surface of the polymers with uniform dispersion of drug. The drug content increased with increased kollidon ratio and decreased sodium alginate ratio. Increased kollidon ratio led to decreased disintegration time due to its insoluble nature and had no effect on sodium alginate ratio. The release rate increased with increase in kollidon ratio and decreased by the addition of sodium alginate. Formulation F 3 showed fast and maximum release which was taken as a best formulation. Thus the fast dissolving films of Diclofenac sodium can be prepared by solvent technique using sodium alginate as film base and kollidon as superdisintegrant.
ACCESSION #
91651765

 

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