TITLE

Adult-Type Hypolactasia in an Ethnic Uzbek Population

AUTHOR(S)
KASIMOV, Sharaf; LEMBER, Margus
PUB. DATE
January 2013
SOURCE
International Journal of Health & Nutrition;2013, Vol. 4 Issue 1, p46
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: To define the prevalence of different allelic variants associated with C/T-13910 genotype polymorphisms in an Uzbek population of the Andijan province and to determine the relationship between C/C-13910 genotyping and milk consumption. Methods: 100 Uzbeks were examined for nucleotide polymorphisms by polymerase chain reaction/restriction fragment length polymorphism. Milk tolerance was analyzed by a questionnaire, developed to assess dyspepsia after milk and dairy consumption. Results: The genetic allele variant C/C-13910, the marker of lactase non-persistence, was found in 81% of cases in the Uzbek population. In 19% of the subjects, the genotype C/T-13910 was found. No statistically significant relationship was found between the lactase deficiency genotype and consumption of milk. The majority of the participants with the genotype C/C-13910 were reported to consume 100 to 200 ml of fresh milk a day. Conclusion: The frequency of lactase deficiency in the selected adult Uzbek population was found to be high. High prevalence of hypolactasia is not associated with abstinence from milk intake.
ACCESSION #
91645477

 

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