TITLE

Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

AUTHOR(S)
Shigdar, Sarah; Macdonald, Joanna; O'Connor, Michael; Tao Wang; Dongxi Xiang; Al. Shamaileh, Hadi; Liang Qiao; Ming Wei; Shu-Feng Zhou; Yimin Zhu; Lingxue Kong; Bhattacharya, Santanu; ChunGuang Li; Wei Duan
PUB. DATE
October 2013
SOURCE
Sensors (14248220);Oct2013, Vol. 13 Issue 10, p13624
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
ACCESSION #
91639397

 

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