Aptamers as Theranostic Agents: Modifications, Serum Stability and Functionalisation

Shigdar, Sarah; Macdonald, Joanna; O'Connor, Michael; Tao Wang; Dongxi Xiang; Al. Shamaileh, Hadi; Liang Qiao; Ming Wei; Shu-Feng Zhou; Yimin Zhu; Lingxue Kong; Bhattacharya, Santanu; ChunGuang Li; Wei Duan
October 2013
Sensors (14248220);Oct2013, Vol. 13 Issue 10, p13624
Academic Journal
Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selection procedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.


Related Articles

  • Advances and Perspectives in Cell-Specific Aptamers. Wei Sun; Lupei Du; Minyong Li // Current Pharmaceutical Design;1/1/2011, Vol. 17 Issue 1, p80 

    No abstract available.

  • Bioinformatic Analysis of the Contribution of Primer Sequences to Aptamer Structures. Cowperthwaite, Matthew C.; Ellington, Andrew D. // Journal of Molecular Evolution;Jul2008, Vol. 67 Issue 1, p95 

    Aptamers are nucleic acid molecules selected in vitro to bind a particular ligand. While numerous experimental studies have examined the sequences, structures, and functions of individual aptamers, considerably fewer studies have applied bioinformatics approaches to try to infer more general...

  • A Mathematical Analysis of Multiple-Target Selex. Yeon-Jung Seo; Shiliang Chen; Nilsen-Hamilton, Marit; Levine, Howard // Bulletin of Mathematical Biology;Oct2010, Vol. 72 Issue 7, p1623 

    SELEX (Systematic Evolution of Ligands by Exponential Enrichment) is a procedure by which a mixture of nucleic acids can be fractionated with the goal of identifying those with specific biochemical activities. One combines the mixture with a specific target molecule and then separates the...

  • A microfluidic SELEX prototype. Hybarger, Glen; Bynum, Joseph; Williams, Robert F.; Valdes, James J.; Chambers, James P. // Analytical & Bioanalytical Chemistry;Dec2005, Vol. 384 Issue 1, p191 

    Aptamers are nucleic acid binding species capable of recognizing a wide variety of targets ranging from small organic molecules to supramolecular structures, including organisms. They are isolated from combinatorial libraries of synthetic nucleic acid by an iterative process referred to as SELEX...

  • RNA Aptamer Evolution: Two Decades of SELEction. Aquino-Jarquin, Guillermo; Toscano-Garibay, Julia D. // International Journal of Molecular Sciences;Dec2011, Vol. 12 Issue 12, p9155 

    Aptamers are small non-coding RNAs capable of recognizing, with high specificity and affinity, a wide variety of molecules in a manner that resembles antibodies. This class of nucleic acids is the resulting product of applying a well-established screening method known as SELEX. First developed...

  • ValFold: Program for the aptamer truncation process. Akitomi, Joe; Kato, Shintaro; Yoshida, Yoshihito; Horii, Katsunori; Furuichi, Makio; Waga, Iwao // Bioinformation;2011, Vol. 7 Issue 1, p38 

    DNA or RNA aptamers have gained attention as the next generation antibody-like molecules for medical or diagnostic use. Conventional secondary structure prediction tools for nucleic acids play an important role to truncate or minimize sequence, or introduce limited chemical modifications without...

  • Third Coast starts Medical Mile development. Nichols, Mike // Grand Rapids Business Journal;7/20/2015, Vol. 33 Issue 29, p12 

    The article reports on the ground-breaking ceremony conducted by commercial real estate development firm Third Coast Development on July 6, 2015 for its new mixed-use building called Third Coast Purple to be constructed at 555 Michigan Street NE in Grand Rapids, Michigan.

  • Molecular Recognition Models: A Challenge to Overcome. Caceres, Rafael Andrade; Pauli, Ivani; Timmers, Luis Fernando Saraiva Macedo; de Azevedo Jr., Walter Filgueira // Current Drug Targets;Dec2008, Vol. 9 Issue 12, p1077 

    Molecular recognition process describes the interaction involving two molecules. In the case of biomolecules, these pairs of molecules could be protein-protein, protein-ligand or protein-nucleic acid. The first model to capture the essential features, behind the molecular recognition problem,...

  • Structural transformation induced by locked nucleic acid or 2′–O-methyl nucleic acid site-specific modifications on thrombin binding aptamer. Bo Liu; Da Li // Chemistry Central Journal;2014, Vol. 8 Issue 1, preceding p1 

    Background Locked nucleic acid (LNA) and 2′-O-methyl nucleic acid (OMeNA) are two of the most extensively studied nucleotide derivatives in the last decades. However, how they affect DNA quadruplex structures remains largely unknown. To explore their possible biological affinities for...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics