TITLE

Genetic polymorphisms in CYP1A1, CYP1B1 and COMT genes in Greenlandic Inuit and Europeans

AUTHOR(S)
Ghisari, Mandana; Long, Manhai; Bonefeld-Jørgensen, Eva C.
PUB. DATE
February 2013
SOURCE
International Journal of Circumpolar Health;2013, Vol. 72, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. The Indigenous Arctic population is of Asian descent their genetic background is different from the Caucasian populations. Relatively little is known about the specific genetic polymorphisms in genes involved in the activation detoxification mechanisms of environmental contaminants in Inuit its relation to health risk. The Greenlandic Inuit are highly exposed to legacy persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) organochlorine pesticides (OCPs) an elucidation of gene-environment interactions in relation to health risks is needed. Objectives. The aim of this study was to determine compare the genotype allele frequencies of the cytochrome P CYP A Ile Val (rs ) CYP B Leu Val (rs ) catechol-Omethyltransferase COMT Val Met (rs ) in Greenlandic Inuit (n=254 ) Europeans (n=262 ) and explore the possible relation between the genotypes serum levels of POPs. Results. The genotype allele frequency distributions of the three genetic polymorphisms differed significantly between the Inuit Europeans. For Inuit the genotype distribution was more similar to those reported for Asian populations. We observed a significant difference in serum polychlorinated biphenyl (CB- ) the pesticide -dichloro- -bis(p-chlorophenyl)-ethylene (p,p'-DDE) levels between Inuit and Europeans for Inuit also associations between the POP levels genotypes for CYP A CYP B and COMT. Conclusion. Our data provide new information on gene polymorphisms in Greenlandic Inuit that might support evaluation of susceptibility to environmental contaminants warrant further studies.
ACCESSION #
91608031

 

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