TITLE

Design and test of noncrosshybridizing oligonucleotide building blocks for DNA computers and nanostructures

AUTHOR(S)
Deaton, Russell; Kim, Jin-Woo; Chen, Junghuei
PUB. DATE
February 2003
SOURCE
Applied Physics Letters;2/24/2003, Vol. 82 Issue 8, p1305
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
DNA oligonucleotides that anneal to form duplexes in specific, planned configurations are a basic construction material for DNA-based computers and nanotechnology. Unplanned duplex configurations introduce errors in computations and defects in structures, and thus, the sequences must be designed to minimize these effects. A software design tool has been developed that uses thermodynamic models of DNA duplex thermal stability and algorithms from graph theory to select good sets of oligonucleotides. An example set was tested in the laboratory, and the designed sequences formed no unplanned duplexes and had no detectable secondary structure.
ACCESSION #
9140723

 

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