Curcumin rendered protection against cadmium chloride induced testicular damage in Swiss albino mice

SINGH, Preeti; DEORA, Kanchan; SANKHLA, Vandana; MOGRA, Priya
December 2012
Journal of Cell & Molecular Biology;Dec2012, Vol. 10 Issue 2, p31
Academic Journal
Fertility interference, regulation and control have become a matter of global concern in order to maintain adequate, sustainable and healthy population. Cadmium is known to interfere with reproductive physiology and adversely affects the process of spermatogenesis, whereas curcumin is known to be a potent, protective herbal derivative, which renders protection at the physiological, metabolic and cellular levels against numerous toxicants. In the present research, four groups of Swiss albino mice, each group consisting of six mice, were treated with cadmium chloride and curcumin. Group 1 was the control group, where mice were administered only vehicle. In the second group, mice were administered only curcumin. In the third group mice were administered single oral dose of CdCl2, 50mg/kg/animal/day, for a day and were left for 15 days. The fourth group was pre-treated with curcumin (10mg/animal/day) for 15 days and on the 16th day they were administered with single oral dose of CdCl2 (50mg/kg/animal). In animals administered only cadmium, significant perturbations were observed in the process of spermatogenesis. In the seminiferous tubules there is loss of cellular contact and associations, as manifested by loss of germ cells. In organisms pre-treated with curcumin, marked decline in histopathological damage was observed, where the loss of germ cells was not so pronounced. Hence, the present research categorically elucidates the protective effect of curcumin against a single high dose of cadmium chloride induced perturbation in the process of spermatogenesis .


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