TITLE

Universal Glove and Gown Use and Acquisition of Antibiotic-Resistant Bacteria in the ICU A Randomized Trial

AUTHOR(S)
Harris, Anthony D.; Pineles, Lisa; Belton, Beverly; Kristie Johnson, J.; Shardell, Michelle; Loeb, Mark; Newhouse, Robin; Dembry, Louise; Braun, Barbara; Perencevich, Eli N.; Hall, Kendall K.; Morgan, Daniel J.
PUB. DATE
October 2013
SOURCE
JAMA: Journal of the American Medical Association;10/16/2013, Vol. 310 Issue 15, p1571
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
IMPORTANCE Antibiotic-resistant bacteria are associated with increased patient morbidity and mortality. It is unknown whether wearing gloves and gowns for all patient contact in the intensive care unit (ICU) decreases acquisition of antibiotic-resistant bacteria. OBJECTIVE To assess whether wearing gloves and gowns for all patient contact in the ICU decreases acquisition of methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) compared with usual care. DESIGN, SETTING, AND PARTICIPANTS Cluster-randomized trial in 20 medical and surgical ICUs in 20 US hospitals from January 4, 2012, to October 4, 2012. INTERVENTIONS In the intervention ICUs, all health care workers were required to wear gloves and gowns for all patient contact and when entering any patient room. MAIN OUTCOMES AND MEASURES The primary outcomewas acquisition of MRSA or VRE based on surveillance cultures collected on admission and discharge from the ICU. Secondary outcomes included individual VRE acquisition, MRSA acquisition, frequency of health care worker visits, hand hygiene compliance, health care-associated infections, and adverse events. RESULTS From the 26 180 patients included, 92 241 swabs were collected for the primary outcome. Intervention ICUs had a decrease in the primary outcome of MRSA or VRE from 21.35 acquisitions per 1000 patient-days (95%CI, 17.57 to 25.94) in the baseline period to 16.91 acquisitions per 1000 patient-days (95%CI, 14.09 to 20.28) in the study period, whereas control ICUs had a decrease in MRSA or VRE from 19.02 acquisitions per 1000 patient-days (95%CI, 14.20 to 25.49) in the baseline period to 16.29 acquisitions per 1000 patient-days (95%CI, 13.48 to 19.68) in the study period, a difference in changes thatwas not statistically significant (difference, -1.71 acquisitions per 1000 person-days, 95%CI, -6.15 to 2.73; P = .57). For key secondary outcomes, therewas no difference in VRE acquisition with the intervention (difference, 0.89 acquisitions per 1000 person-days; 95%CI, -4.27 to 6.04, P = .70), whereas for MRSA, there were fewer acquisitions with the intervention (difference, -2.98 acquisitions per 1000 persondays; 95%CI, -5.58 to -0.38; P = .046). Universal glove and gown use also decreased health care worker room entry (4.28 vs 5.24 entries per hour, difference, -0.96; 95%CI, -1.71 to -0.21, P = .02), increased room-exit hand hygiene compliance (78.3%vs 62.9%, difference, 15.4%; 95%CI, 8.99%to 21.8%; P = .02) and had no statistically significant effect on rates of adverse events (58.7 events per 1000 patient days vs 74.4 events per 1000 patient days; difference, -15.7; 95%CI, -40.7 to 9.2, P = .24). CONCLUSIONS AND RELEVANCE The use of gloves and gowns for all patient contact compared with usual care among patients in medical and surgical ICUs did not result in a difference in the primary outcome of acquisition of MRSA or VRE. Although there was a lower risk of MRSA acquisition alone and no difference in adverse events, these secondary outcomes require replication before reaching definitive conclusions. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT0131821
ACCESSION #
91248192

 

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