Monkey tests force rethink on AIDS vaccine

Brown, Phyllida
September 1991
New Scientist;9/21/91, Vol. 131 Issue 1787, p14
The article reports on findings from AIDS vaccine experiments on monkeys at Great Britain's Research Council which undermine earlier studies. Some researchers now think they should completely revise their approach to understanding the way the body protects itself against retroviruses, the family that includes HIV. The team studied antibodies from macaques used in previous vaccine experiments. They found the same pattern of immune response in animals that had received a vaccine based on killed simian immunodeficiency virus alone, without human cells. But the vaccine had been cultured in human cells. Researchers know that proteins from the cells can become incorporated into the virus.


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