Evaluation of neutrophil gelatinase-associated lipocalin in pediatric patients with acute rotavirus gastroenteritis and dehydration

Çelik, Tanju; Altekin, Emel; İşgüder, Rana; Kenesari, Yasin; Duman, Murat; Arslan, Nur
January 2013
Italian Journal of Pediatrics;2013, Vol. 39 Issue 1, p52
Academic Journal
Background: Dehydration caused by acute rotavirus gastroenteritis is a frequent finding in pediatric patients. The most important treatment modality in these patients is recognising and treating dehydration, electrolyte imbalance and acute kidney injury. Neutrophil gelatinase-asssociated lipocalin (NGAL) is used widely as a biomarker for the diagnosis of acute or chronic renal injury in numerous clinical studies. It is recognized as an early marker of acute renal failure before the elevation of routine biochemical tests such as creatinine. The aim of this study is to investigate the plasma and urine NGAL concentrations in mildly or moderately dehydrated patients with acute rotavirus gastroenteritis. Material and methods: A total of 30 patients (13 girls, mean age 62.5 ± 46.2 months) with diarrhea and mild/moderate dehydration and 35 healthy controls (17 girls, mean age 81.1 ± 41.8 months) were enrolled in the study. Plasma and urine NGAL levels of the two groups were compared. Results: The mean age, gender and serum creatinine levels of the patients and healthy controls were similar. The mean plasma and urine NGAL levels of the patients were significantly higher than controls (plasma: 118.6 ± 81.2 vs. 66.5 ± 11.3, p = 0.001 and urine: 17.7 ± 17.5 vs. 10.6 ± 7.9, p = 0.035, respectively). Conclusion: Mildly or moderately dehydrated children have higher plasma and urine NGAL levels compared to control subjects. Plasma and/or urine NGAL levels can be used for the early prediction of renal impairment in children with mild or moderate dehydration.


Related Articles

  • Endocan—A Novel Inflammatory Indicator in Newly Diagnosed Patients With Hypertension: A Pilot Study. Balta, Sevket; Mikhailidis, Dimitri P.; Demirkol, Sait; Ozturk, Cengiz; Kurtoglu, Ertugrul; Demir, Mustafa; Celik, Turgay; Turker, Turker; Iyisoy, Atila // Angiology;Oct2014, Vol. 65 Issue 9, p773 

    Endothelial dysfunction is regarded as the initial lesion in the development of atherosclerosis. Endocan, previously called endothelial cell–specific molecule 1 (ESM-1), is a new candidate immunoinflammatory marker that may be associated with cardiometabolic risk factors. Therefore, we...

  • The association between anti-plasminogen antibodies and disease activity in ANCA-associated vasculitis. Hao, Jian; Wang, Chen; Gou, Shen-ju; Zhao, Ming-Hui; Chen, Min // Rheumatology;Feb2014, Vol. 53 Issue 2, p300 

    Objective. Previous studies have shown that in patients with ANCA-associated vasculitis (AAV), anti-plasminogen antibodies were associated with reduced renal function and the presence of fibrinoid necrosis and cellular crescents in renal histology. The purpose of the current study was to...

  • Urinary CD80 levels as a diagnostic biomarker of minimal change disease. Ling, Chen; Liu, Xiaorong; Shen, Ying; Chen, Zhi; Fan, Jianfeng; Jiang, Yeping; Meng, Qun // Pediatric Nephrology;Feb2015, Vol. 30 Issue 2, p309 

    Background: Early diagnosis of minimal change disease (MCD) in nephrotic syndrome (NS) patients remains challenging. Doctors often make a diagnosis of MCD using invasive renal biopsy. CD80, a transmembrane protein, is present on podocytes in a number of experimental models of NS. Urinary CD80...

  • Risk factors for the development of osteoporosis after spinal cord injury. A 12-month follow-up study. Gifre, L.; Vidal, J.; Carrasco, J.; Muxi, A.; Portell, E.; Monegal, A.; Guañabens, N.; Peris, P. // Osteoporosis International;Sep2015, Vol. 26 Issue 9, p2273 

    Summary: Spinal cord injury (SCI) has been associated with a marked bone loss after injury and a consequent increased risk of osteoporosis. The evaluation of bone mineral density shortly after SCI is a simple and effective method for predicting the development of osteoporosis during the first...

  • Galectin-3 and Plasma Cytokines in Patients With Acute Myocardial Infarction. Alturfan, A. Ata; Basar, Isık; Emekli-Alturfan, Ebru; Ayan, Faruk; Koldas, Lale; Emekli, Nesrin // Laboratory Medicine;Fall2014, Vol. 45 Issue 4, p336 

    Objective: To investigate the concentrations of plasma cytokines and Galectin-3 (Gal-3) as inflammatory markers in patients with acute myocardial infarction (AMI). Methods: The study population consisted of 29 patients with AMI and 29 healthy control subjects. We measured Gal-3, tumor necrosis...

  • Idiopathic inflammatory myositis-associated interstitial lung disease: ethnicity differences and lung function trends in a British cohort. Chua, Felix; Higton, Alexandra M.; Colebatch, Alexandra N.; O'reilly, Katherine; Grubnic, Sisa; Vlahos, Ioannis; Edwards, Christopher J.; Kiely, Patrick D. W. // Rheumatology;Oct2012, Vol. 51 Issue 10, p1870 

    Objective. Interstitial lung disease (ILD) is an important feature of idiopathic inflammatory myositis (IIM). Factors associated with its development and progression remain incompletely understood. The authors report ethnicity differences and lung function trends that characterize the...

  • Extra-pulmonary tuberculosis: a biomarker analysis. Fortún, J.; Martín-Dávila, P.; Gómez-Mampaso, E.; Vallejo, A.; Cuartero, C.; González-García, A.; Rubí, J.; Pallarés, E.; Moreno, S. // Infection;Aug2014, Vol. 42 Issue 4, p649 

    Introduction: Studies on biomarkers in tuberculosis are focused on pulmonary forms of this disease (PTB), and only limited information is currently available on biomarkers of extra-pulmonary tuberculosis (EPTB). Methods: Serum samples from 24 patients with PTB, 29 patients with EPTB and 27...

  • Egy-Score Predicts Severe Hepatic Fibrosis and Cirrhosis in Egyptians With Chronic Liver Diseases: A Pilot Study. Alboraie, Mohamed A.; Afifi, Mahmoud E.; Elghamry, Fathy G.; Shalaby, Helmy A.; Elshennawy, Gamal E.; Abdelaziz, Ahmed A.; Shaheen, Mohamed U.; Abo El-Seoud, Amany R. // Hepatitis Monthly;Jun2013, Vol. 13 Issue 6, p1 

    Background: Non-invasive methods for assessment of hepatic fibrosis are increasingly needed. Recent studies showed that combined elevation of tumor markers CA 19-9 and CA 125 is predictive of severe hepatic fibrosis or cirrhosis with high specificity. Objectives: We aimed at developing a new...

  • Cystatin C in acute kidney injury diagnosis: early biomarker or alternative to serum creatinine? Lagos-Arevalo, Paola; Palijan, Ana; Vertullo, Laura; Devarajan, Prasad; Bennett, Michael; Sabbisetti, Venkata; Bonventre, Joseph; Ma, Qing; Gottesman, Ronald; Zappitelli, Michael // Pediatric Nephrology;Apr2015, Vol. 30 Issue 4, p665 

    Background: Early acute kidney injury (AKI) diagnosis is needed to pursue treatment trials. We evaluated cystatin C (CysC) as an early biomarker of serum creatinine (SCr)-AKI and an alternative to define AKI. Methods: We studied 160 non-cardiac children in the intensive care unit (ICU). We...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics