TITLE

Aggregation of lipoprotein(a) to apolipoprotein A-I underlying HDL dysfunction as a major coronary risk factor

AUTHOR(S)
Onat, Altan; Can, Giinay; Murat, Sani; Çiçek, Gökhan; Örnek, Ender; Yüksel, Hüşniye
PUB. DATE
September 2013
SOURCE
Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi;Sep2013, Vol. 13 Issue 6, p543
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Dysfunction of high-density lipoprotein (HDL) may contribute to coronary heart disease (CHD) risk. We determined whether aggregation to lipoprotein (Lp)(a) of apolipoprotein (apo) A-I underlies HDL dysfunction conferring incident CHD risk. Methods: A representative sample of 1509 middle-aged Turkish adults was studied at 4.9-years' follow-up yielding 198 incident CHD cases. Statistical analysis was performed using multiple linear regression and Cox proportional regression analyses. Results: In women, not age or apoA-l, rather complement C3, apoE levels and statin use were linearly related to log-Lp(a). Individuals in the low Lp(a) tertile (<6.4 mg/dL) displayed high mean triglyceride and apoE values, and geometric mean Lp(a) values increased moderately in subjects having low and mid tertiles of apoE or triglycerides, only to be lower in the high tertiles (p<0.002). These two findings indicated the unexpected fall in Lp(a) under circumstances of high apo E (>4.5 mg/dL) and/or triglycerides (>2.0 mmol/L). Levels actually represent aggregation of Lp(a) to apoA-l in an immune complex, rendering apoA-l atherogenic. Lp(a) did not, but apoA-l did significantly predict incident CHD (HR 1.21 [95%CI 1.07; 1.37]) in Cox regression analyses after adjustment for conventional risk factors and statin use. This adverse action of apoA-l was independent of prevalent metabolic syndrome (MetS), existed in individuals in whom ATPIII-defined MetS was not identified, and was similar in magnitude to that of conventional risk factors. Conclusion: Beyond being atherogenic, Lp(a) may aggregate in a pro-inflammatory milieu to apoA-l, rendering apoA-l atherogenic. This process is independent of ATPIII-defined MetS and exhibits risk magnitude similar to that of conventional risk factors.
ACCESSION #
90646328

 

Related Articles

  • Antihypertensive Treatment, High Triglycerides, and Low High-Density Lipoprotein Cholesterol and Risk of Ischemic Heart Disease Mortality: A 16-Year Follow-Up in the Copenhagen Male Study. Poul Suadicani; Hans Ole Hein; Finn Gyntelberg // Metabolic Syndrome & Related Disorders;Jun2010, Vol. 8 Issue 3, p215 

    AbstractObjective:The aim of this study was to test the hypothesis that metabolic syndrome dyslipidemia is a major risk factor for ischemic heart disease (IHD) mortality among men taking antihypertensive medication.Methods:This was a 16-year follow up of 2,986 men 53–75 years old without...

  • Mortality risk of triglyceride levels in patients with coronary artery disease. Kasai, Takatoshi; Miyauchi, Katsumi; Yanagisawa, Naotake; Kajimoto, Kan; Kubota, Naozumi; Ogita, Manabu; Tsuboi, Shuta; Amano, Atsushi; Daida, Hiroyuki // Heart;Jan2013, Vol. 99 Issue 1, p22 

    Objective The association between triglyceride level and the risk of coronary artery disease (CAD) remains controversial. In particular, the prognostic significance of triglyceride levels in established CAD is unclear. We aimed to assess the relationship between triglyceride levels and long-term...

  • HDL-cholesterol and triglycerides: an overlooked issue? Twomey, P. J.; Pledger, D. R. // Journal of Clinical Pathology;Sep2007, Vol. 60 Issue 9, p1065 

    The article presents a case study of the relationship between high-density lipoprotein-cholesterol (HDL-C) and triglyceride concentrations. According to the findings of several prospective clinical trials and epidemiological studies, a low concentration of HDL-C is an independent risk factor for...

  • Elevated serum uric acid in nondiabetic people mark pro-inflammatory state and HDL dysfunction and independently predicts coronary disease. Onat, Altan; Can, Günay; Örnek, Ender; Altay, Servet; Yüksel, Murat; Ademoğlu, Evin // Clinical Rheumatology;Dec2013, Vol. 32 Issue 12, p1767 

    We explored the association of serum uric acid (UA) concentrations with pro-inflammatory state and high-density lipoprotein (HDL) dysfunction. UA tertiles in tracked 1,508 nondiabetic participants were analyzed cross-sectionally for associations with inflammation biomarkers and protective...

  • Serum cholesterol as a risk factor for coronary heart disease revisited. Rossouw, J. E. // South African Journal of Clinical Nutrition;2015, Vol. 28 Issue 1, p34 

    The biology of lipoproteins and lipoprotein particles as mediators of atherosclerosis has been documented extensively. Numerous prospective epidemiological studies have shown a robust relationship between low-density lipoprotein (LDL) cholesterol, or particles bearing apolipoprotein B, and...

  • "Good" Cholesterol Not Always Good?  // IDEA Fitness Journal;Sep2012, p18 

    The article reports that according to the researchers from the Harvard School of Public Health, apolipoprotein (apo) C-lll found on the surface of High-density lipoprotein increases the risk for coronary heart disease (CHD).

  • The Emerging Risk Factors Collaboration. Major lipids, Apolipoproteins, and Risk of Vascular Disease. Kile, Debra H. // Journal of Insurance Medicine;2010, Vol. 42 Issue 1, p45 

    The article discusses research being done on the association between major lipids and apolipoproteins, and the risk of developing vascular disease. It references a study published in a 2009 issue of the "Journal of the American Medical Association." For the study, researchers examined 68 studies...

  • LIPID MANAGEMENT.  // Monthly Prescribing Reference;May2015, Vol. 31 Issue 5, p18 

    The article offers information on various factors to consider during lipid and non-lipid risk factors treatment. Topics discussed include the importance of achieving low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) treatment goal, the effective use of...

  • LIPID MANAGEMENT.  // Monthly Prescribing Reference;May2013, Vol. 29 Issue 5, p20 

    The article discusses the lipid management for lowering the Low-density lipoprotein-cholesterol (LDL-C) in the treatment of coronary heart disease (CHD). It states that Therapeutic Lifestyle Changes (TLC) is the first-line therapy for higher risk patients of CHD. It discusses the management of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics