TITLE

Cadmium Exposure and Nephropathy in a 28-Year-Old Female Metals Worker

AUTHOR(S)
Wittman, Richard; Hu, Howard
PUB. DATE
December 2002
SOURCE
Environmental Health Perspectives;Dec2002, Vol. 110 Issue 12, p1261
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A 28-year-old female presented for evaluation of left flank pain and polyuria after having been exposed to cadmium in the jewelry manufacturing industry for approximately 3 years. This patient possessed both elevated 24-hr urinary β[sub 2]-microglobulin and elevated blood cadmium levels. Approximately 6 months after initial presentation, the patient resigned from her job due to shortness of breath, chest pain, and anxiety. Exposure to cadmium in the jewelry industry is a significant source of occupational cadmium exposure. Other occupational sources include the manufacture of nickel-cadmium batteries, metal plating, zinc and lead refining, smelting of cadmium and lead, and production of plastics. Cadmium is also an environmental pollutant that accumulates in leafy vegetables and plants, including tobacco. Major toxicities anticipated from cadmium exposure involve the renal, pulmonary, and, to a lesser extent, gastrointestinal systems. These include the development of renal proximal tubular dysfunction, glomerutar damage with progressive renal disease, and respiratory symptoms including pneumonitis and emphysema. Low-level cadmium exposure has also been associated with increased urinary calcium excretion and direct bone toxicity, effects that recent research suggests may result in the development of osteoporosis. The body burden of cadmium, over half of which may reside in the kidneys, is most often measured through the use of urinary cadmium levels. Blood cadmium measurements generally reflect current or recent exposure and are especially useful in cases with a short exposure period and only minimal accumulation of cadmium in the kidneys. Both β[sub 2]-microglobulin and α[sub 1]-microglobulin serve as organ-specific, early-effect biomarkers of tubular proteinuria and thus play a role in identifying early signs of cadmium-induced renal damage in those with potential exposures. In addition to ensuring workplace compliance with Occupational Safety...
ACCESSION #
9062078

 

Related Articles

  • Estimation of the benchmark dose of urinary cadmium as the reference level for renal dysfunction: a large sample study in five cadmium polluted areas in China. Shen Ke; Xi-Yu Cheng; Jie-Ying Zhang; Wen-Jing Jia; Hao Li; Hui-Fang Luo; Peng-He Ge; Ze-Min Liu; Hong-Mei Wang; Jin-Sheng He; Zhi-Nan Chen // BMC Public Health;Jul2015, Vol. 15 Issue 1, p1 

    Background: Itai-itai disease primarily results from cadmium (Cd) exposure and is known as one of the four major pollution diseases in Japan. Cd pollution is more serious in several areas of China than in Japan. However, there is still a lack of information regarding the threshold level of Cd...

  • End stage renal disease among ceramic workers exposed to silica. Rapiti, E.; Sperati, A.; Miceli, M.; Forastiere, F.; Di Lallo, D.; Cavariani, F.; Goldsmith, D.F.; Perucci, C.A. // Occupational & Environmental Medicine;Aug1999, Vol. 56 Issue 8, p559 

    Analyzes the effects of exposure to silica among ceramic workers. Risk of renal disease among ceramic workers; Toxic effects of silica.

  • Mortality from nephritis and nephrosis in the fibreglass manufacturing industry. Chiazze, L.; Watkins, D.K.; Fryar, C.; Fayerweather, W.; Bender, J.R.; Chiazze, M. // Occupational & Environmental Medicine;Mar1999, Vol. 56 Issue 3, p164 

    Examines the association between exposure to respirable glass fibre and mortality from nephritis and nephrosis among workers in fibrous glass wool manufacturing industry. Lack of consistent relation of respirable fibres with nephritis and nephrosis; Mortality rates related with nephritis and...

  • A patient who changed my practice: Fifteen years before looking at job.  // BMJ: British Medical Journal (International Edition);9/15/2001, Vol. 323 Issue 7313, p628 

    Relates the author's experience treating a man with chronic abdominal pain and hypertension. Lack of a previous diagnosis; Discovery that he worked in a ceramic industry; Test performed which resulted in a diagnosis of lead-nephropathy; Treatment; Thoughts on the importance of asking patients...

  • Early Kidney Damage in a Population Exposed to Cadmium and Other Heavy Metals. Thomas, Laura D. K.; Hodgson, Susan; Nieuwenhuijsen, Mark; Jarup, Lars // Environmental Health Perspectives;Feb2009, Vol. 117 Issue 2, p181 

    BACKGROUND: Exposure to heavy metals may cause kidney damage. The population living near the Avonmouth zinc smelter has been exposed to cadmium and other heavy metals for many decades. OBJECTIVES: We aimed to assess Cd body burden and early signs of kidney damage in the Avonmouth population....

  • Cadmium impact on animal growth. Golueke, Clarence // BioCycle;Apr95, Vol. 36 Issue 4, p30 

    Presents an abstract of the article `Distribution of Cadmium and Its Influence on the Growth of Offspring After an Experimental Application to Female Rabbits,' by P. Massanyi, V. Ubrfm and R. Toman, published in the `Journal of Environmental Science and Health.'

  • Cd isotopic signatures: a potential source tracer of metal pollution in the environment. Gao, Bo // Environmental Science & Pollution Research;Jan2016, Vol. 23 Issue 1, p941 

    A letter to the editor about cadmium as a potential source tracer of metal pollution in the environment is presented.

  • Erratum to: Can ligand addition to soil enhance Cd phytoextraction? A mechanistic model study. Lin, Zhongbing; Schneider, André; Nguyen, Christophe; Sterckeman, Thibault // Environmental Science & Pollution Research;Apr2015, Vol. 22 Issue 7, p5587 

    A correction to the article "Can Ligand Addition to Soil Enhance Cd Phytoextraction? A Mechanistic Model Study" that was published in the November, 2014 issue is presented.

  • Cadmium exposure among residents in an area contaminated by irrigation water in China. Cai, S.; Yue, L. // Bulletin of the World Health Organization;1995, Vol. 73 Issue 3, p359 

    Reports on cadmium exposure among residents of Dayu County, Jiangxi Province, China due to pollution of the river water used to irrigate its arable land. Cadmium from tailings and wastewater of tungsten ore dressing plants; Estimates of oral cadmium intake coming from locally grown rice and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics