Optical biosensors in drug discovery

Cooper, Matthew A.
July 2002
Nature Reviews Drug Discovery;Jul2002, Vol. 1 Issue 7, p515
Academic Journal
Optical biosensors that exploit surface plasmon resonance, waveguides and resonant mirrors have been used widely over the past decade to analyse biomolecular interactions. These sensors allow the determination of the affinity and kinetics of a wide variety of molecular interactions in real time, without the need for a molecular tag or label. Advances in instrumentation and experimental design have led to the increasing application of optical biosensors in many areas of drug discovery, including target identification, ligand fishing, assay development, lead selection, early ADME and manufacturing quality control. This article reviews important advances in optical-biosensor instrumentation and applications, and also highlights some exciting developments, such as highly multiplexed optical-biosensor arrays.


Related Articles

  • Optical Biosensors as a Tool for Early Determination of Absorption and Distribution Parameters of Lead Candidates and Drugs. Bertucci, Carlo; Piccoli, Angela; Pistolozzi, Marco // Combinatorial Chemistry & High Throughput Screening;Jul2007, Vol. 10 Issue 6, p433 

    Specific molecular interactions provide a fundamental mechanism for selectivity in every aspect of biological structure and function. The ability to measure quantitatively such interaction properties across a wide range of affinity, size, and purity is a growing need. A short review on the use...

  • Optical Chemical Biosensors for High Throughput Screening of Drugs. Bosch, Maria E.; S�nchez, Antonio J. R.; Rojas, Fuensanta S.; Ojeda, Catalina B. // Combinatorial Chemistry & High Throughput Screening;Jul2007, Vol. 10 Issue 6, p413 

    Optical biosensors have been commercially available since the early 1990s, and have been used extensively in many areas of research in the life sciences. Optical biosensors developed for drug analysis generally exploit the high selectivity of the antigen-antibody and drug-protein interaction....

  • Tilted FBGs excite optical-fiber plasmons. Albert, Jacques; Shevchenko, Yanina // Laser Focus World;Jan2010, Vol. 46 Issue 1, p71 

    The article discusses the development of the surface plasmon resonance (SPR) technique that detects chemical and biochemical changes that occur between molecules. The technique is a plasmon-based detector created from a standard single-mode optical fiber and uses tilted fiber Bragg gratings and...

  • Sensitivity Enhancement of Biochemical Sensors Based on Er+3 Doped Microsphere Coupled to an External Mirror. Bahrampour, Alireza; Azhir, Azam Gholampour; Taghiabadi, Razie; Yazdi, kazem Rahimi // Sensors & Transducers (1726-5479);Sep2010, Vol. 120 Issue 9, p152 

    In this paper we proposed an active optical sensor designed based on the Er+3 -doped microsphere coupled to an external mirror. The microsphere-mirror coupling causes the degeneracy splitting of the resonance frequencies. Each of resonance frequencies splits in to two different resonance...

  • Europt(r)ode X : Tenth European conference on optical chemical sensors and biosensors. Krieg, A. Katrin; Furin, Dominik; Albrecht, Christiane; Kolarov, Felix; Ewald, Melanie // Analytical & Bioanalytical Chemistry;Nov2010, Vol. 398 Issue 5, p1863 

    The article discusses highlights of the Europt(r)ode X Conference in Prague, the Czech Republic from March 28-31, 2010. The conference on optochemical sensing and biosensing was attended by 244 delegates from 25 countries. Presentations were made on integrated optical systems, micro, nano and...

  • Direct optical detection in fragment-based screening. Pröll, Florian; Fechner, Peter; Proll, Günther // Analytical & Bioanalytical Chemistry;Mar2009, Vol. 393 Issue 6/7, p1557 

    Label-free biosensors based on direct optical detection principles are widely used in many different fields of research. Currently the higher level of automation and the increasing throughput of this technology are stimulating the interest of pharmaceutical companies. The information gained with...

  • The physics of extreme sensitivity in whispering gallery mode optical biosensors. Lopez-Yglesias, Xerxes; Gamba, Jason M.; Flagan, Richard C. // Journal of Applied Physics;Apr2012, Vol. 111 Issue 8, p084701 

    Whispering gallery mode (WGM) optical biosensors are capable of extraordinarily sensitive specific and nonspecific detection of species suspended in a gas or fluid. Recent experimental results suggest that these devices may attain single-molecule sensitivity to protein solutions in the form of...

  • Optical Microarray Grating Biosensors. Chathirat, Naphat; Hruanun, Charndet; Poyai, Amporn // Applied Mechanics & Materials;2015, Vol. 804, p155 

    An optical biosensor based on a grating to be utilized for the detection of DNA target molecules was fabricated by photolithographic techniques. The sensor surface implements a grating to create a low effective refractive index platform via the combination of Si3N4 and SiO2 which allows the...

  • Direct optical sensors: principles and selected applications. Gauglitz, Guenter // Analytical & Bioanalytical Chemistry;Jan2005, Vol. 381 Issue 1, p141 

    In the field of bio and chemosensors a large number of detection principles has been published within the last decade. These detection principles are based either on the observation of fluorescence-labelled systems or on direct optical detection in the heterogeneous phase. Direct optical...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics