TITLE

Preliminary Toxicological Evaluation of some Biochemical Parameters and Lipid Profile in Thevetia Neriifolia Seed Oil Supplemented Diet in Albino Rats

AUTHOR(S)
NWOZO, Sarah Onyenibe; AJAYI, Ibironke Adetolu; IORLIAM, Bridget Ebehiremen
PUB. DATE
January 2013
SOURCE
Leonardo Electronic Journal of Practices & Technologies;Jan-Jun2013, Issue 22, p43
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Thevetia Neriifolia was analyzed for fatty acid composition by using Gas Chromatography (GC) and Gas Chromatography-Mass Spectrophotometer (GC-MS). The oil consist of 97.583% fatty acid of which the most abundant is the monounsaturated (C18H34O2) Oleic acid (52%), and the others are saturated fatty acids (C18H36O2) Stearic acid (25%) and the other Palmitic acid (C16H32O2). The physicochemical studies of the seed oil showed: acid value of 0.515 ± 0.27 mg KOH/g; 117.125±2.38 saponification value and 74.145 ± 0.784 iodine value. Growth performance in albino rats following a feeding period of 6 weeks, using 5%, 10% and 15% of the seed oil compounded feed showed a significant decrease in body weight gain and feed intake in 10% and 15% oil-based feed group relative to control. Enzymatic antioxidant, biomarkers of kidney/liver toxicity and lipid profile of visceral organs were evaluated.
ACCESSION #
90594935

 

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