TITLE

Antioxidant effect on brain tissue and sciatic nerve of sildenafil: An experimental diabetic rats model

AUTHOR(S)
Arikanoglu, Adalet; Alp, Harun; Yuksel, Hatice; Ozkan, Umit
PUB. DATE
September 2013
SOURCE
HealthMed;2013, Vol. 7 Issue 9, p2572
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and Aim: Oxidative stress known to play a role in pathogenesis of involvement of both central and peripheral nervous system in diabetes. The aim of this study was to investigate if sildenafil has a protective effect on injury atic nerve and brain tissue of diabetic rats. Methods: A total of 36 rats was divided into groups as control group (n=9), diabetic group (n= only Streptozotocin), diabetic group given sildenafil (n=9, Streptozotocin +), and the group given sildenafil only (n=9). Total oxidant status, oxidative stress index, malondialdehyde, total antioxidant status, and catalase levels were measured to assess oxidative stress in brain and sciatic nerves of the rats. Results: Total oxidant status, oxidative stress index, malondialdehyde levels in brain and sciatic nerve of diabetic rats were significantly higher compared to controls (p<0.05), whereas total antioxidant status and catalase levels were significantly lower (p<0.05). Diabetic group given sildenafil had a significantly lower. Total oxidant status, oxidative stress index, malondialdehyde levels (p<0.05), and significantly higher total antioxidant status and catalase levels (p<0.05) in brain and sciatic nerve compared to diabetic group. Conclusion: This study showed that sildenafil has a protective effect on the damage in both brain tissue and sciatic nerve of the diabetic rats due to oxidative stress.
ACCESSION #
90572196

 

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