TITLE

Emerging Roles of Small Epstein-Barr Virus Derived Non-Coding RNAs in Epithelial Malignancy

AUTHOR(S)
Raymond Wai-Ming Lung; Joanna Hung-Man Tong; Ka-Fai To
PUB. DATE
September 2013
SOURCE
International Journal of Molecular Sciences;Sep2013, Vol. 14 Issue 9, p17378
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Latent Epstein-Barr virus (EBV) infection is an etiological factor in the progression of several human epithelial malignancies such as nasopharyngeal carcinoma (NPC) and a subset of gastric carcinoma. Reports have shown that EBV produces several viral oncoproteins, yet their pathological roles in carcinogenesis are not fully elucidated. Studies on the recently discovered of EBV-encoded microRNAs (ebv-miRNAs) showed that these small molecules function as post-transcriptional gene regulators and may play a role in the carcinogenesis process. In NPC and EBV positive gastric carcinoma (EBVaGC), 22 viral miRNAs which are located in the long alternative splicing EBV transcripts, named BamH1 A rightward transcripts (BARTs), are abundantly expressed. The importance of several miR-BARTs in carcinogenesis has recently been demonstrated. These novel findings enhance our understanding of the oncogenic properties of EBV and may lead to a more effective design of therapeutic regimens to combat EBV-associated malignancies. This article will review the pathological roles of miR-BARTs in modulating the expression of cancer-related genes in both host and viral genomes. The expression of other small non-coding RNAs in NPC and the expression pattern of miR-BARTs in rare EBV-associated epithelial cancers will also be discussed.
ACCESSION #
90529601

 

Related Articles

  • Recent Insights and Novel Bioinformatics Tools to Understand the Role of MicroRNAs Binding to 5' Untranslated Region. Da Sacco, Letizia; Masotti, Andrea // International Journal of Molecular Sciences;Jan2013, Vol. 14 Issue 1, p480 

    MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression through the binding of the 3' untranslated region (3'UTR) of specific mRNAs. MiRNAs are post-transcriptional regulators and determine the repression of translation processes or the degradation of mRNA targets. Recently,...

  • MicroRNAs in the Neural Retina. Andreeva, Kalina; Cooper, Nigel G. F. // International Journal of Genomics;2014, p1 

    The health and function of the visual system rely on a collaborative interaction between diverse classes of molecular regulators. One of these classes consists of transcription factors, which are known to bind to DNA and control the transcription activities of their target genes. For a long...

  • Non-Coding RNAs in Retinal Development. Maiorano, Nicola A.; Hindges, Robert // International Journal of Molecular Sciences;Jan2012, Vol. 13 Issue 1, p558 

    Retinal development is dependent on an accurately functioning network of transcriptional and translational regulators. Among the diverse classes of molecules involved, non-coding RNAs (ncRNAs) play a significant role. Members of this family are present in the cell as transcripts, but are not...

  • A Transgenic Transcription Factor (TaDREB3) in Barley Affects the Expression of MicroRNAs and Other Small Non-Coding RNAs. Hackenberg, Michael; Shi, Bu-Jun; Gustafson, Perry; Langridge, Peter; Alvarez, M. Lucrecia // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Transcription factors (TFs), microRNAs (miRNAs), small interfering RNAs (siRNAs) and other functional non-coding small RNAs (sRNAs) are important gene regulators. Comparison of sRNA expression profiles between transgenic barley overexpressing a drought tolerant TF (TaDREB3) and non-transgenic...

  • Biogenesis of Epstein-Barr virus microRNAs. Kim, Do; Lee, Suk // Molecular & Cellular Biochemistry;Jun2012, Vol. 365 Issue 1/2, p203 

    Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus implicated in lymphomas, such as Burkitt's lymphoma, Hodgkin's lymphoma, and NK/T cell lymphoma. MicroRNAs (miRNAs) are 19-25 nucleotide long single-stranded RNAs involved in post-transcriptional gene regulation. miRNAs are mainly...

  • miR-18a promotes malignant progression by impairing microRNA biogenesis in nasopharyngeal carcinoma. Luo, Zhaohui; Dai, Yafei; zhang, Liyang; Jiang, Chen; Li, Zheng; Yang, Jianbo; McCarthy, James B.; She, Xiaoling; Zhang, Wenling; Ma, Jian; Xiong, Wei; Wu, Minghua; Lu, Jianhong; Li, Xiayu; Li, Xiaoling; Xiang, Juanjuan; Li, Guiyuan // Carcinogenesis;Feb2013, Vol. 34 Issue 2, p415 

    Dysregulation of microRNA (miRNA) biogenesis is implicated in cancer development and progression. Dicer and Drosha are established regulators of miRNA biogenesis. In this study, we used a miRNA array to evaluate the miRNA expression profiles in nasopharyngeal carcinoma (NPC) samples. The...

  • Small RNA: Long-lived microRNA complexes. Muers, Mary // Nature Reviews Genetics;Feb2013, Vol. 14 Issue 2, p78 

    The article discusses a research entitled "Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses," by S. H. Olejniczak, which suggested that miRNA complexes could allow cells to retain long-term information for post-transcriptional regulation.

  • Transcribe this way: Rap1 confers promoter directionality by repressing divergent transcription. Wu, Andrew C.K.; Van Werven, Folkert J. // Transcription (2154-1264);Jun2019, Vol. 10 Issue 3, p164 

    In eukaryotes, divergent transcription is a major source of noncoding RNAs. Recent studies have uncovered that in yeast, the transcription factor Rap1 restricts transcription in the divergent direction and thereby controls promoter directionality. Here, we summarize these findings, propose...

  • The EBV lytic switch protein, Z, preferentially binds to and activates the methylated viral genome. Bhende, Prasanna M; Seaman, William T; Delecluse, Henri-Jacques; Kenney, Shannon C // Nature Genetics;Oct2004, Vol. 36 Issue 10, p1099 

    DNA methylation promotes gene silencing, yet the Epstein-Barr virus immediate-early protein, BZLF1 (Z), converts the virus from the latent to the lytic form of infection even when the viral genome is highly methylated. Here we show that methylation of CpG motifs in Z-responsive elements of the...

Share

Read the Article

Courtesy of

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics