TITLE

Development and Validation of Stability Indicating RP-HPLC Method of Analysis of Manidipine Dihydrochloride

AUTHOR(S)
Prashant L. Pingale; Bhavisa S. Topiwala
PUB. DATE
April 2013
SOURCE
International Journal of ChemTech Research;Apr-Jun2013, Vol. 5 Issue 2, p1770
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A stability indicating isocratic, rapid high performance liquid chromatographic method was developed and validated for its determination. The determination was performed on a Kromasil ODS C18 column (100 × 4.6 mm, 5μ) column with mobile phase consist of ACN - Water (85:15) at a flow rate 1 ml min-1 at UV detection wavelength of 229.36 nm. Manidipine Dihydrochloride was found to degrade in acidic and alkaline stress conditions. The drug was stable to Hydrogen peroxide and dry heat. The validation studies were carried out fulfilling ICH requirements. The procedure was found to be linear, precise, and accurate.
ACCESSION #
90515876

 

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