Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?

Verner, Marc-André; McDougall, Robin; Glynn, Anders; Andersen, Melvin E.; Clewell III, Harvey J.; Longnecker, Matthew P.
October 2013
Environmental Health Perspectives;Oct2013, Vol. 121 Issue 10, p1219
Academic Journal
Background: A recent meta-analysis based on data from > 7,000 pregnancies reported an association between prenatal polychlorinated biphenyl (PCB)-153 exposure and reduced birth weight. Gestational weight gain, which is associated negatively with PCB levels in maternal and cord blood, and positively with birth weight, could substantially confound this association. Objective: We sought to estimate the influence of gestational weight gain on the association between PCB-153 exposure and birth weight using a pharmacokinetic model. Methods: We modified a recently published pharmacokinetic model and ran Monte Carlo simula­tions accounting for variability in physiologic parameters and their correlations. We evaluated the pharmacokinetic model by comparing simulated plasma PCB-153 levels during pregnancy to serial measurements in 10 pregnant women from another study population. We estimated the association between simulated plasma PCB-153 levels and birth weight using linear regression models. Results: The plasma PCB-153 level profiles generated with the pharmacokinetic model were com­parable to measured levels in 10 pregnant women. We estimated a 118-g decrease in birth weight (95% CI: -129, -106 g) for each 1-μg/L increase in simulated cord plasma PCB-153, compared with the 150-g decrease estimated based on the previous meta-analysis. The estimated decrease in birth weight was reduced to -6 g (95% CI: -18, 6 g) when adjusted for simulated gestational weight gain.


Related Articles

  • Maternal protein intake during pregnancy and offspring overweight 20 y later. Maslova, Ekaterina; Rytter, Dorte; Bech, Bodil H.; Henriksen, Tine B.; Rasmussen, Morten A.; Olsen, Sjurdur F.; Halldorsson, Thorhallur I. // American Journal of Clinical Nutrition;Oct2014, Vol. 100 Issue 4, p1139 

    Background: Animal studies have shown that protein intake in pregnancy may influence offspring fat metabolism and adiposity. The macronutrient ratio in human pregnancy appears to be important for offspring glucose tolerance; however, less is known about the influence on offspring adiposity....

  • Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study. Starling, Anne P.; Brinton, John T.; Glueck, Deborah H.; Shapiro, Allison L.; Harrod, Curtis S.; Lynch, Anne M.; Siega-Riz, Anna Maria; Dabelea, Dana // American Journal of Clinical Nutrition;Feb2015, Vol. 101 Issue 2, p302 

    Background: Maternal obesity and weight gain during pregnancy are risk factors for child obesity. Associations may be attributable to causal effects of the intrauterine environment or genetic and postnatal environmental factors. Objective: We estimated associations of maternal prepregnancy body...

  • Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study. Chen, Aimin; Yolton, Kimberly; Rauch, Stephen A.; Webster, Glenys M.; Hornung, Richard; Sjödin, Andreas; Dietrich, Kim N.; Lanphear, Bruce P. // Environmental Health Perspectives;Aug2014, Vol. 122 Issue 8, p856 

    Background: Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades. Objective: We examined whether in utero exposure to PBDEs is associated...

  • Prenatal Methylmercury, Postnatal Lead Exposure, and Evidence of Attention Deficit/Hyperactivity Disorder among Inuit Children in Arctic Québec. Boucher, Olivier; Jacobson, Sandra W.; Plusquellec, Pierrich; Dewailly, Éric; Ayotte, Pierre; Forget-Dubois, Nadine; Jacobson, Joseph L.; Muckle, Gina // Environmental Health Perspectives;Oct2012, Vol. 120 Issue 10, p1456 

    Background: Prenatal exposure to methyl mercury (MeHg) and polychlorinated biphenyls (PCBs)has been associated with impaired performance on attention tasks in previous studies, but the extent to which these cognitive deficits translate into behavioral problems in the classroom and attention...

  • The Impact of Extremes in Outdoor Temperature and Sunshine Exposure on Birth Weight. Poeran, Jashvant; Birnie, Erwin; Steegers, Eric A. P. // Journal of Environmental Health;Jan/Feb2016, Vol. 78 Issue 6, p92 

    Following the "fetal origins of adult disease" hypothesis, environmental determinants of birth weight regained interest. The authors applied a detailed spatial-time exposure model for climatological factors thought to affect fetal growth: seasonality, temperature, and sunshine. Daily...

  • Relationship Between Prenatal Lead Exposure and Infant Blood Lead Levels. Archer, Natalie; Bradford, Carrie; Klein, David; Barnes, Jim; Smith, L.; Villanacci, John // Maternal & Child Health Journal;Oct2012, Vol. 16 Issue 7, p1518 

    Recent literature has shown that analyzing newborn dried blood spots (DBS) may be effective in assessing some prenatal environmental exposures, such as exposure to lead. The purpose of this study was to evaluate the relationship between prenatal exposure to lead (as measured by newborn DBS...

  • Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort (Crete, Greece). Vafeiadi, Marina; Georgiou, Vaggelis; Chalkiadaki, Georgia; Rantakokkoa, Panu; Kiviranta, Hannu; Karachaliou, Marianna; Fthenou, Eleni; Venihaki, Maria; Sarri, Katerina; Vassilaki, Maria; Kyrtopoulos, Soterios A; Oken, Emily; Kogevinas, Manolis; Chatzi, Leda // Environmental Health Perspectives;Oct2015, Vol. 123 Issue 10, p1015 

    BACKGROUND: Prenatal exposure to endocrine-disrupting chemicals such as persistent organic pollutants (POPs) may increase risk of obesity later in life. OBJECTIVE: We examined the relation of in utero POPs exposure to offspring obesity and cardio-metabolic risk factors at 4 years of age in the...

  • Birth Weight and Prenatal Exposure to Polychlorinated Biphenyls (PCBs) and Dichlorodiphenyldichloroethylene (DDE): A Meta-analysis within 12 European Birth Cohorts. Govarts, Eva; Nieuwenhuijsen, Mark; Schoeters, Greet; Ballester, Ferrari; Bloemen, Karolien; Boer, Michiel de; Chevrier, Cécile; Eggesbø, Merete; Guxens, Mònica; Krämer, Ursula; Legler, Juliette; Martínez, David; Palkovicova, Lubica; Patelarou, Evridiki; Ranft, Ulrich; Rautio, Arja; Petersen, Maria Skaalum; Slama, Rémy; Stigum, Hein; Toft, Gunnar // Environmental Health Perspectives;Feb2012, Vol. 120 Issue 2, p162 

    OBJECTIVES: Exposure to high concentrations of persistent organochlorines may cause fetal toxicity, but the evidence at low exposure levels is limited. Large studies with substantial exposure contrasts and appropriate exposure assessment are warranted. Within the framework of the EU (European...

  • Predicting Behaviors to Reduce Toxic Chemical Exposures Among New and Expectant Mothers. Mello, Susan; Hovick, Shelly R. // Health Education & Behavior;Dec2016, Vol. 43 Issue 6, p705 

    There is a growing body of evidence linking childhood exposure to environmental toxins and a range of adverse health outcomes, including preterm birth, cognitive deficits, and cancer. Little is known, however, about what drives mothers to engage in health behaviors to reduce such risks. Guided...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics