Hipernatremia en 79 recién nacidos. Factores asociados a desenlace adverso

López-Candiani, Carlos; Salamanca-Galicia, Omar
September 2012
Acta Pediatrica de Mexico;sep/oct2012, Vol. 33 Issue 5, p239
Academic Journal
Background. Hypernatremia is a pathologic condition that is potentially complicated with neurologic damage or death. The aim of the present was to detect factors associated to adverse outcome in hypernatraemic infant newborns. Material and method. A retrospective study was conducted in newborns (NB) from March 1st, 2001 to February 28th, 2011 in a pediatric specialties hospital. 79 patients were included. Age mean was 9 days, birth weight mean was 3143 g. Weight loss median was 19%. Demographic, clinical, biochemical, therapeutic, complications and outcome data were recorded. Variables were compared between newborns with adverse and those with favorable outcome. Results. 76% of the NB was exclusively breastfed. More than a half had fever, dried mucosa, jaundice and refused to feed; 38% had hypoglycemia and 86% renal failure. Mean serum sodium was 165 mEq/L and hourly descent was 0.63mEq/L. 38% had neurologic abnormal findings and 5% died. Adverse outcome was associated to weight loss > 18% (OR 3, 95% CI 1.1-7.7), serum sodium ≥ 170 mEq/L (OR 14, 95%CI 4.5-47) and sodium descent > 0.6 mEq/L/h (OR 3, 95%CI 1.2-7.8). Conclusions. The longer a newborn remains with low feeding, the more factors associate to an adverse outcome.


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