TITLE

Synthesis and Antitumor Activity of 17-carboxylic acid Modified Amide Derivatives of 23-hydroxy betulinic acid

AUTHOR(S)
Yi Bi; Jin-Yi Xu; Fei Sun; Xiao-Ming Wu; Wen-Cai Ye; Yi-Jun Sun; Qing-Guo Meng; Wen-Wen Huang
PUB. DATE
October 2013
SOURCE
Records of Natural Products;Oct2013, Vol. 7 Issue 4, p254
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A novel series of 17-carboxylic acid modified amide derivatives of 23-hydroxy betulinic acid (1) were prepared and tested in vitro against five cell lines: A549 (human lung carcinoma), BEL-7402 (human hepatoma), SF-763 (human cerebroma), B16 (mice melanoma) and HL-60 (human leukaemia). Within this series of compounds, 4a (IC50 =21.08 µM in SF-763, IC50=21.63 µM in HL-60), 4b (IC50=28.45 µM in HL-60,IC50=29.32 µM in BEL-7402 ) and 6g (IC50=26.09 µM in BEL-7402, IC50=22.65 µM in HL-60) have the more potent cytotoxic activity than lead compound 1. The preliminary structure-activity relationship analysis of the C-28 amide derivatives is also discussed.
ACCESSION #
90487568

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics