TITLE

Effect of Oxymetholone medicine by mother treatment during Pregnancy and lactation period on FSH, LH and Testosterone hormones in mature newborn male rats

AUTHOR(S)
Khajehei, Mona; Jahromi, Vahid Hemayatkhah; Zolqhadri, Samaneh; Kargar, Hossein
PUB. DATE
July 2012
SOURCE
Advances in Environmental Biology;Jul2012, Vol. 6 Issue 8, p2410
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and Purpose: Oxymetholone is an active nutritional anabolic steroid -- androgenic that is used as energetic medicine in high doses which may result some abnormalities such as lung cancer, mineral deposits in lung, ovarian cycle irregularity, adrenal benign tumor, liver cancer and adenoma in renal tubes. The aim of this study was to investigate Oxymetholone induced complication on testosterone, LH, FSH hormones concentration levels in mature newborn male rats. Their mothers were treated by this medicine in different pregnancy and lactation period. Materials and methods: 56 female rats and 14 wistar male rats were singled out in this study. They were at the age of 110-120 days after birth and their weights were approximately 200±20 gr. The animals were divided into 7 groups of 8 including control, solvent 1 (pregnancy-21 days), solvent 2 (pregnancy-lactation-42days), solvent 3 (lactation--21 days), experimental 1 (pregnancy-21 days), experimental 2 (pregnancy-lactation-42 days) and experimental 3 (lactation-21 days). Solvent groups used DMSO as Oxymetholone solvent with 99.5% purity and experimental groups used Oxymetholone with 10 mg/kg concentration by intra peritoneum method. The hormones concentration was measured by radio immunoassay method. Results: The LH level indicated significant decrease in experimental groups of pregnancy-lactation and lactation. FSH in experimental groups of pregnancy-lactation, lactation and also Testosterone in experimental groups of pregnancy-lactation were reduced in comparison to control group. Conclusion: Oxymetholone may results negative feedback induce to reduce LH, FSH and testosterone concentration with mentioned dose which lead to disorder in reproductive system of wistar male rats.
ACCESSION #
90477988

 

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