Effect of Ethanol Extract of Root Turnip (Brassica rapa) on Changes in Blood Factors HDL, LDL, Triglycerides and Total Cholesterol in Hypercholesterolemic Rabbits

Mirzaie, Hamide; Johari, Habibollah; Najafian, Mahmood; Kargar, Hossein
September 2012
Advances in Environmental Biology;Sep2012, Vol. 6 Issue 10, p2796
Academic Journal
Background: The expression of myocardial infarction and cerebral atherosclerosis is responsible for most cases in the United States and Western Europe. Research shows that over the past decade in most countries the use of alternative therapies and especially herbal therapy and dietary supplements to improve a variety of illnesses, including high blood fat, has increased. Therefore, the aim of this study is to investigate the effect of different doses of turnip juice on blood lipid changes in hypercholesterolemic rabbits. Methods: In this study, 30 adult female rabbits produced 5 to 6 equal groups: control, sham 1, sham 2, and treatments 1, 2 and 3 respectively. Extract at doses of 100, 200, 400 mg / kg body weight of the rabbits in groups 1, 2 and 3 with 1 g/kg cholesterol and 1 ml/kg of corn oil to the was given as gavage. Cholesterol group 1 and group 2 sham group received the same amount of corn oil. Studies were performed on blood factors and body weight changes and test data by ANOVA (One-way analysis of variance) at a significant level (P< 0/01) was determined by using SPSS version 15. Results: The results for total cholesterol in all treatment groups and one sham group were significantly increased. LDL in groups 1 and 2, and 1 have seen a significant increase compared with control requirements. HDL in the treatment group and sham 2 is a significant increase. Triglycerides in treatment group 1 and sham 1 is a significant increase compared to the control group (P< 0/01) .The body weight of the animals in the treatment groups, sham 1 and 2 has been significantly lower than the control group. The results shows that the turnip root extract can probably little that can prevent the occurrence of atherosclerotic due to flavonoids and vitamins in it.


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