TITLE

The effects of hydro alcoholic extract of Ceratonia siliqua L. seeds on pituitary -- testis hormones and spermatogenesis in rat

AUTHOR(S)
Mokhtari, M.; Sharifi, E.; Azadian, Sh
PUB. DATE
September 2012
SOURCE
Advances in Environmental Biology;Sep2012, Vol. 6 Issue 10, p2778
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In traditional medicine, Carob tree has been used as antidiarrheal medicine and to treat digestion diseases. In this research, the possible effects of Carob seeds extract on levels of LH, FSH, testosterone and dihydrotestosterone hormones and testicular tissue as well as improving fertility in male rats were investigated. Fifty adult male rats were divided into five groups of tens as follow: The control group was left on treated, the sham group received only distilled water and experimental groups which received 150,300 and 600 (mg/kg) extract respectively for 31 days. Blood samples were taken to measure LH, FSH, testosterone and dihydrotestosterone concentrations and testicular histological changes was investigated. The consumption of Carob seeds extract caused a significant increase in testosterone and DHT concentrations were as the level of LH declined in experimental groups receiving 150 and 300 (mg/kg) extract and the FSH concentrations did not show any significant changes. Furthermore, sperm density in seminiferous tubules was increased in response to medium and high dosages of the extract. The seed extract of Carob may have some effects on the synthesis of cAMP and the activities of enzymes involved in steroidogenesis in leydig cells thereby leading to an increase in serum concentration of testosterone.
ACCESSION #
90476839

 

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