TITLE

Protective effect of Aloe Vera Leaves Extract on Hepatic Tissue Injury in Streptozotocin-induced Diabetic Rats

AUTHOR(S)
Bahram Amouoghli Tabrizi; Daryoush Mohajeri
PUB. DATE
September 2012
SOURCE
Advances in Bioresearch;Sep2012, Vol. 3 Issue 3, p67
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The negative impact of diabetes on the liver is well recognized. This study was designed to evaluate the hepatoprotective properties of Aloe vera (Aloe barbadensis Miller) leaves extract in streptozotocin-induced diabetes in rats. Male Wistar rats were made diabetic with a single injection of STZ (65 mg/kg i.p.). Rats were randomly allocated into four groups, 10 animals each: Group 1, healthy control rats; Group 2 non-diabetic rats treated with 50 mg/kg b.w./day i.p. injection of Aloe vera extract; Group 3, diabetic rats; Group 4, diabetic rats treated with the extract (50 mg/kg b.w./day, i.p.) for 8 weeks. Finally, serum AST, ALT, ALP and albumin levels as well as liver MDA, GSH contents and activities of GSH-Px, SOD and CAT were measured to assess hepatic injury. Liver MDA content and serum ALT, AST, AP and bilirubin levels in Groups 3 were found to be significantly increased as compared to Group 1 (P<0.05) and these parameters in Group 4 were significantly decreased as compared to Group 3 (P<0.05). Liver GSH, SOD, CAT and GSH-Px contents and serum albumin level in Group 3 was significantly decreased as compared to Group 1 (P<0.05) and were found to be significantly increased in Group 4 as compared to Groups 3 (P<0.05). Histopathological changes were in agreement with biochemical findings. This study showed that Aloe vera extract have hepatoprotective effects in experimentally induced diabetic rats.
ACCESSION #
90473886

 

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