TITLE

Anti-inflammatory activity of acetonic extract of Pistacia lentiscus fruits

AUTHOR(S)
Bouriche, Hammama; Khalfaoui, Safia; Meziti, Hichem; Senotor, Abderrahmane
PUB. DATE
July 2013
SOURCE
Turkish Online Journal of Science & Technology;Jul2013, Vol. 3 Issue 3, p40
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Pistacia lentiscus L. (P. lentiscus) has traditionally been used as a stimulant, for its diuretic properties, and to treat hypertension, coughs, sore throats, eczema, stomach aches, kidney stones and jaundice. In the present study, the antiinflammatory effect of acetonic extract of P. lentiscus fruits was evaluated. The quantitative estimation of total phenolic compounds showed that the acetonic extract is rich in polyphenols (250.6 ± 14 μg GAE/mg of extract) and flavonoïds (20.6 ± 5.8μg QE/mg of extract). The anti-inflammatory activity of P. lentiscus was evaluated in vivo using the ear edema model induced by Croton oil and the air pouch model induced by Lambda carrageenan. Three treatments were used. The simultaneously use of the extract (3mg of extract/ear) with the irritant agent, the topic use of 3mg of extract/ear and oral administration of 300mg of extract/kg 1hour before the induction of the inflammation. Results obtained showed that P. lentiscus extract inhibited significantly the ear edema by the percentages of 68%, 72% and 80%, respectively. These inhibitions were statistically similar to the effect of indomethacin used as a standard anti-inflammatory agent. On the other hand, an inhibitory activity of leukocytes migration was observed in the murine air pouch exudate. The treatment by acetonic extract (1mg/pouch) decreased significantly the number of leucocytes in the air-pouch (34%). This inhibition was statistically similar to the effect of indomethacin. Finally, we can conclude that the acetonic extract of P. lentiscus fruits have a considerable anti-inflammatory activity, which support the use of this plant specially their fruits in folkloric medicine.
ACCESSION #
90473239

 

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