TITLE

Garlic intake is an independent predictor of endothelial function in patients with ischemic stroke

AUTHOR(S)
Lau, K.; Chan, Y.; Wong, Y.; Teo, K.; Yiu, K.; Liu, S.; Li, L.; Shu, X.; Ho, S.; Chan, K.; Siu, C.; Tse, Hung
PUB. DATE
July 2013
SOURCE
Journal of Nutrition, Health & Aging;Jul2013, Vol. 17 Issue 7, p600
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objetives: To investigate the effects of garlic on endothelial function in patients with ischemic stroke (ISS). Design: Cross-sectional study. Participants: 125 Chinese patients with prior ISS due to athero-thrombotic disease were recruited from the outpatient clinics during July 2005 to December 2006. Measurements: Daily allium vegetable intake (including garlic, onions, Chinese chives and shallots) was ascertained by means of a validated food frequency questionnaire for Chinese and brachial artery flow-mediated dilatation (FMD) was measured using high-resolution ultrasound in all subjects. Results: The mean age of the study population was 65.9±11.1 years and 69% were males. Mean allium vegetable intake and garlic intake of the study population was 7.5±12.7g/day and 2.9±8.8g/day respectively. Their mean FMD was 2.6±2.3%. Daily intake of total allium vegetable (r=0.36, P<0.01) and garlic (r=0.34, P<0.01) significantly correlated with FMD. Using the median daily allium intake as cut-off (3.37g/day), patients with a low allium intake <3.37g/day was noted to have a lower FMD compared to those with a normal allium intake (2.1±2.1% versus 3.0±2.4%, P<0.05). After adjusting for confounding factors, multi-variate analysis identified that daily allium vegetable (B=0.05, 95% confidence interval: 0.02, 0.09, P<0.01) and garlic (B=0.07, 95% confidence interval: 0.02, 0.12, P<0.01) intake, but not onions, Chinese chives and shallots were independent predictors for changes in FMD in patients with ISS. Conclusions: Daily garlic intake is an independent predictor of endothelial function in patients with ISS and may play a role in the secondary prevention of atherosclerotic events.
ACCESSION #
90470647

 

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