TITLE

Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences

AUTHOR(S)
Pillay, Janesh; Tak, Tamar; Kamp, Vera; Koenderman, Leo
PUB. DATE
October 2013
SOURCE
Cellular & Molecular Life Sciences;Oct2013, Vol. 70 Issue 20, p3813
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Neutrophils are essential effector cells in the host defense against invading pathogens. Recently, novel neutrophil functions have emerged in addition to their classical anti-microbial role. One of these functions is the suppression of T cell responses. In this respect, neutrophils share similarities with granulocytic myeloid-derived suppressor cells (G-MDSCs). In this review, we will discuss the similarities and differences between neutrophils and G-MDSCs. Various types of G-MDSCs have been described, ranging from immature to mature cells shaping the immune response by different immune suppressive mechanisms. However, all types of G-MDSCs share distinct features of neutrophils, such as surface markers and morphology. We propose that G-MDSCs are heterogeneous and represent novel phenotypes of neutrophils, capable of suppressing the immune response. In this review, we will attempt to clarify the differences and similarities between neutrophils and G-MDSCs and attempt to facilitate further research.
ACCESSION #
90374600

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics