Fluoroquinolone Resistance in Streptococcus pyogenes

Richter, Sandra S.; Diekema, Daniel J.; Heilmann, Kris P.; Almer, Laurel S.; Shortridge, VIrginia D.; Zeitler, Rod; Flamm, Robert K.; Doern, Gary V.
February 2003
Clinical Infectious Diseases;2/1/2003, Vol. 36 Issue 3, p380
Academic Journal
Streptococcus pyogenes isolated from blood and urine samples obtained from a 78-year-old woman was tested for susceptibility, and fluoroquinolone resistance (minimum inhibitory concentration of levofloxacin, 16 µg/mL) was found. DNA amplification and sequencing revealed a serine[sup 81]→ tyrosine substitution in gyrA and 2 substitutions in parC: serine[sup 79]→phenylalanine and alanine[sup 121]→valine. This is the second report of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.


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