TITLE

Evaluation of the Immunochromatographic Binax NOW Assay for Detection of Streptococcus pneumoniae Urinary Antigen in a Prospective Study of Community-Acquired Pneumonia in Spain

AUTHOR(S)
Gutiérrez, Félix; Masiá, Mar; Rodriguez, J. Carlos; Ayelo, Antonio; Soldán, Bernardo; Cebrián, Laura; Mirete, Carlos; Royo, Gloria; Hidalgo, Alberto M.
PUB. DATE
February 2003
SOURCE
Clinical Infectious Diseases;2/1/2003, Vol. 36 Issue 3, p286
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We evaluated the Binax NOW rapid immunochromatographic membrane test (ICT) for detection of Streptococcus pneumoniae urinary antigen in a population-based prospective study of adults with communityacquired pneumonia (CAP). ICT was performed with urine samples obtained from 452 (91.7%) of 493 patients enrolled. Pneumococcal antigen was detected in 19 (70.4%) of 27 patients with pneumococcal pneumonia. The test results were more frequently positive for patients who had not received antibiotics before testing (26.6% vs. 12.1%; P = .002). Only 16 (10.3%) of 156 samples obtained from patients with nonpneumococcal pneumonia yielded a positive result. Of the 269 patients who had pneumonia with no pathogen identified, antigen was detected in 69 (25.7%). With conventional microbiological criteria used as the "gold standard," the test had a sensitivity of 70.4% and a specificity of 89.7%. Testing concentrated urine samples with the ICT may be a useful technique for rapid diagnosis of pneumococcal pneumonia in adults with CAP.
ACCESSION #
9027377

 

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