Association between FAT Gene and Schizophrenia in the Korean Population

Young-Eun Jung; Tae-Youn Jun
August 2013
Clinical Psychopharmacology & Neuroscience;Aug2013, Vol. 11 Issue 2, p67
Academic Journal
Objective: The aim of this study was to investigate the genetic association of the FAT gene with schizophrenia in the Korean population, as well as analyzing the association of FAT gene with clinical variables. Methods: Four variants within the FAT gene were investigated in 189 patients with schizophrenia and 119 healthy controls (rs2306987 A/C, rs2306990 T/C, rs2637777 G/T, and rs2304865 G/C). Results: Significant association at the rs273777 with schizophrenia was observed; however, rs2306987, rs2306990, and rs2304865 were not associated with schizophrenia. Haplotype analyses revealed that the haplotype A/T/T/G was associated with a significantly protective effect. Sliding window analysis (rs2637777 G/T and rs2304865 G/C) revealed the more common T/G haplotype, included in the A/T/T/G protective combination, showed a small protective effect, in particular the effect was due to the rs273777 T variant (minor allele). Conclusion: The present finding suggests that FAT polymorphism may play a putative role in the susceptibility to schizophrenia in the Korean population. Further studies using a larger number of subjects should be performed to determine whether the FAT gene polymorphism may be truly involved in the development of schizophrenia.


Related Articles

  • ASSOCIATION OF E-CADHERIN GENE 3'-UTR C/T POLYMORPHISM WITH ENDOMETRIOSIS. Emam, Wafaa A.; Etewa, Rasha L.; Mostfa, Ali Abdelhamed M. // Egyptian Journal of Biochemistry & Molecular Biology;Dec2012, Vol. 30 Issue 2, p104 

    Endometriosis (EM) is one of the most frequent diseases in gynecology; endometriotic cells display invasive characteristics, despite their benign histological appearance. Epithelial-cadherin (E-cadherin) is a cell-cell adhesive molecule which maintains cell integrity and communication between...

  • Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease. Ding, Keyue; Kullo, Iftikhar J. // BMC Medical Genetics;2011, Vol. 12 Issue 1, p55 

    Background: We hypothesized that the frequencies of risk alleles of SNPs mediating susceptibility to cardiovascular diseases differ among populations of varying geographic origin and that population-specific selection has operated on some of these variants. Methods: From the database of...

  • Association analysis of polymorphisms in the prepronociceptin gene and schizophrenia. Imai, K.; Harada, S.; Kawanishi, Y.; Tachikawa, H.; Okubo, T.; Suzuki, T. // Journal of Human Genetics;2001, Vol. 46 Issue 8, p442 

    The human prepronociceptin (ppNoc) gene is located on chromosome 8p21, and several linkage studies have suggested that the susceptibility locus for schizophrenia is present in this chromosomal region. We investigated genetic variations in the promoter and coding regions of the ppNoc gene to...

  • Genetic polymorphism analysis of killer cell immunoglobulin-like receptor genes in the Chinese Uygur population. Wang, Hong-dan; Zhu, Bo-feng; Shen, Chun-mei; Yuan, Guo-lian; Yang, Guang; Guo, Juan-ning; Yan, Jiang-wei; Qin, Hai-xia; Guo, Jian-xin; Zhang, Li-ping; Jia, Xiao-qin; Lucas, Rudolf // Molecular Biology Reports;Mar2012, Vol. 39 Issue 3, p3017 

    Human killer cell immunoglobulin-like receptors are expressed in natural killer cells and subsets of T lymphocytes. They regulate these cells upon interaction with human leukocyte antigen class I molecules and other ligands presented by target cells. KIR gene frequencies and haplotype...

  • Association of B3GNT5 Polymorphisms with Susceptibility to ETEC F4ab/ac in the White Duroc × Erhualian Intercross and 15 Outbred Pig Breeds. Ouyang, Jing; Zeng, Weihong; Ren, Jun; Yan, Xueming; Zhang, Zhiyan; Yang, Ming; Han, Pengfei; Huang, Xiang; Ai, Huashui; Huang, Lusheng // Biochemical Genetics;Jan2012, Vol. 50 Issue 1/2, p19 

    The B3GNT5 gene is a candidate for the F4ab/ac receptor conferring susceptibility to enterotoxigenic Escherichia coli (ETEC) F4ab/ac in pigs. In this study, we screened mutations in the complete coding region of the porcine B3GNT5 gene and identified four SNPs in the 3′ untranslated...

  • Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility. Minashkin, Mikhail; Salnikova, Lubov; Lomonosov, Konstantin; Korobko, Igor; Tatarenko, Andrey // Archives of Dermatological Research;Apr2013, Vol. 305 Issue 3, p233 

    Vitiligo is an acquired pigmentary disorder with several proposed pathogenesis mechanisms and complex multifactorial genetic predisposition. We analyzed 65 polymorphisms in genes potentially relevant to vitiligo pathogenesis mechanism to reveal novel and confirm reported genetic risk factors in...

  • Polymorphisms and Haplotypes in Candidate Genes Related to Angiogenesis and Endothelial Dysfunction in Preeclampsia. Luizon, Marcelo Rizzatti; Taveiros Palei, Ana Carolina; Sandrim, Valeria Cristina // Journal of Pregnancy;2012, p1 

    Valenzuela and colleagues have recently reviewed some polymorphisms in important candidate genes involved in different pathogenic mechanisms related to preeclampsia (PE) and concluded that various studies in different populations have identified maternal polymorphisms associated with PE....

  • Immunogenetic Factors Affecting Susceptibility of Humans and Rodents to Hantaviruses and the Clinical Course of Hantaviral Disease in Humans. Charbonnel, Nathalie; Pagès, Marie; Sironen, Tarja; Henttonen, Heikki; Vapalahti, Olli; Mustonen, Jukka; Vaheri, Antti // Viruses (1999-4915);May2014, Vol. 6 Issue 5, p2214 

    We reviewed the associations of immunity-related genes with susceptibility of humans and rodents to hantaviruses, and with severity of hantaviral diseases in humans. Several class I and class II HLA haplotypes were linked with severe or benign hantavirus infections, and these haplotypes varied...

  • MCP-1, CCR2 and CCR5 Polymorphisms in Tunisian Patients with Atopic Asthma. Dhaouadi, Tarak; Sfar, Imen; Aounallah-Skhiri, Hajer; Jendoubi-Ayed, Saloua; Bouacha, Hend; Abdallah, Taieb Ben; Gorgi, Yousr // Iranian Journal of Allergy, Asthma & Immunology;Mar2013, Vol. 12 Issue 1, p29 

    Chemokines and their receptors play an important role in the late inflammatory stage of asthma. In this study, we aimed to investigate polymorphisms of MCP-1 (CCL2), CCR2 and CCR5 which can affect qualitatively and/or quantitatively their production and thus influence both susceptibility and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics