Inhibition of mutant troponin C activity by an intra-domain disulphide bond

Grabarek, Z.; Tannebaum, R.
May 1990
Nature;5/10/1990, Vol. 345 Issue 6271, p132
Academic Journal
Describes a mutant troponin C (TnC) in which the key conformational transition and the calcium-regulatory activity are reversibly blocked by the formation of a disulphide bridge. Mutant TnC design; Reactivity of thiol groups in mutant TnC; Ca2+ binding properties of TnC4882; Interaction of TnC4882 with TnI and TnT; Regulatory activity.


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