Hypovitaminosis D is Independently Associated with Metabolic Syndrome in Obese Patients

Barchetta, Ilaria; De Bernardinis, Marzia; Capoccia, Danila; Baroni, Marco Giorgio; Fontana, Mario; Fraioli, Antonio; Morini, Sergio; Leonetti, Frida; Cavallo, Maria Gisella
July 2013
PLoS ONE;Jul2013, Vol. 8 Issue 7, p1
Academic Journal
Background: Metabolic syndrome (MS) and hypovitaminosis D represent two of the most diffuse condition worldwide, reaching pandemic proportions in industrialized countries, and are both strongly associated with obesity. This study set out to evaluate the presence of an independent association between hypovitaminosis D and MS in an adult population of obese subjects with/without MS. Methods: We recruited 107 consecutive obese subjects, 61 with MS (age(mean±SD) 45.3±13.3 years, BMI(mean±SD): 43.1±8.3 kg/m2) and 46 without MS (age: 41.8±11.5, p = n.s., BMI:41.6±6.5 kg/m2, p = n.s.) comparable for sex, BMI, waist circumference and body fat mass, evaluated by bioimpedentiometry. 25(OH) vitamin D3 levels were measured by colorimetric method. Insulin resistance was estimated by fasting blood insulin, HOMA-IR and ISI. Results: Serum 25(OH)D3 levels were significantly lower in MS obese patients than in obese subjects without MS (median(range) 13.5(3.3–32) vs 17.4(5.1–37.4), p<0.007). Low 25(OH)D3 levels correlated with glycaemia (p<0.007), phosphate (p<0.03), PTH (p<0.003) and the MS (p<0.001). Multivariate model confirmed that low 25(OH)D3 levels were associated with the diagnosis of MS in obese patients independently from gender, age, serum PTH and body fat mass. After stratifying the study population according to 25(OH)D3 concentrations, patients in the lowest quartile showed a markedly increased prevalence of MS compared to those in the highest quartile (OR = 4.1, CI 1.2–13.7, p = 0.02). Conclusions: A powerful association exists between hypovitaminosis D and MS in obese patients independently from body fat mass and its clinical correlates. This indicates that the association between low 25(OH) D3 levels and MS is not merely induced by vitamin D deposition in fat tissue and reinforces the hypothesis that hypovitaminosis D represent a crucial independent determinant of MS.


Related Articles

  • Waist-to-Height Ratio Is a Better Anthropometric Index than Waist Circumference and BMI in Predicting Metabolic Syndrome among Obese Mexican Adolescents. Rodea-Montero, Edel Rafael; Evia-Viscarra, María Lola; Apolinar-Jiménez, Evelia // International Journal of Endocrinology;2014, p1 

    Objective. To identify the degree of association between anthropometric indices and components of metabolic syndrome (MS) and to determine optimal cut-off points of these indices for predicting MS in obese adolescents. Methods. A cross-sectional study with a sample of (n = 110) Mexican obese...

  • Waist Girth Does Not Predict Metabolic Complications in Severely Obese Men. Lemieux, Isabelle; Drapeau, Vicky; Richard, Denis; Bergeron, Jean; Marceau, Picard; Biron, Simon; Mauriège, Pascale // Diabetes Care;Jun2006, Vol. 29 Issue 6, p1417 

    The article discusses a study on the relationships between selected features of metabolic syndrome and waist circumference as a crude marker of abdominal obesity in moderately and severely obese men. The study found that the prevalence of the syndrome among severely obese men is not as high as...

  • Serum 25-hydroxyvitamin D Concentrations and Metabolic Syndrome in Egyptian Men. Alsayed, Ahmed; Gad, Adela; Azab, Adel // Journal of Medical Sciences;2007, Vol. 7 Issue 5, p850 

    Aim of the study is to investigate the correlations between serum concentrations of 25-hydroxyvitamin [25(OH)D] and components of metabolic syndrome in Egyptian men. Ninety-three Egyptian men with metabolic syndrome and seventy age matched healthy males were included in this study. Metabolic...

  • OBESITY--CLINICAL TREATMENT.  // Diabetes;Jun2008 Supplement 1, Vol. 57, pA736 

    The article presents abstracts of research on clinical treatment for obesity, which includes articles on body volume index, factor structure of the power of food scale in obese patients with diabetes, and correlation between gamma glutamyl transferase levels and metabolic syndrome parameters in...

  • Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study. Song, Yun-Mi; Sung, Joohon; Lee, Kayoung // Clinical & Experimental Nephrology;Oct2015, Vol. 19 Issue 5, p887 

    Background: To examine cross-sectional and longitudinal relationships, including genetic and environmental correlations, of metabolic syndrome (MetS) and obesity with kidney function. Methods: Subjects were 3,437 Korean adults of the Healthy Twin Study for cross-sectional relationships and 1,881...

  • Obesity management in Prader–Willi syndrome: current perspectives. Crinò, Antonino; Fintini, Danilo; Bocchini, Sarah; Grugni, Graziano // Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy;Oct2018, Vol. 11, p579 

    Prader–Willi syndrome (PWS) is a complex multisystem disorder due to the absent expression of the paternally active genes in the PWS critical region on chromosome 15 (15q11.2-q13). The syndrome is considered the most common genetic cause of obesity, occurring in 1:10,000–1:30,000...

  • Continuous Positive Airway Pressure Therapy Improves Hypoadiponectinemia in Severe Obese Men With Obstructive Sleep Apnea Without Changes in Insulin Resistance. Gláucia Carneiro; Sônia Maria Togeiro; Fernando Flexa Ribeiro-Filho; Eveli Truksinas; Artur Beltrame Ribeiro; Maria Teresa Zanella; Sérgio Tufik // Metabolic Syndrome & Related Disorders;Dec2009, Vol. 7 Issue 6, p537 

    Background:Obstructive sleep apnea (OSA) is associated with several conditions that could facilitate the onset of cardiovascular and metabolic dysfunctions. Continuous positive airway pressure (CPAP) therapy has been shown to improve cardiovascular morbidity and mortality related to OSA, but the...

  • Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients - a randomized double-blind placebo-controlled pilot study. Sharafedtinov, Khaider K.; Plotnikova, Oksana A.; Alexeeva, Ravilay I.; Sentsova, Tatjana B.; Songisepp, Epp; Stsepetova, Jelena; Smidt, Imbi; Mikelsaar, Marika // Nutrition Journal;2013, Vol. 12, p29 

    Background Gut lactobacilli can affect the metabolic functions of healthy humans. We tested whether a 1500 kcal/d diet supplemented with cheese containing the probiotic Lactobacillus plantarum TENSIA (Deutsche Sammlung für Mikroorganismen, DSM 21380) could reduce some symptoms of metabolic...

  • OBESITY PHENOTYPES IN URBAN MIDDLE-CLASS COHORTS; THE PRIT-LINDAVISTA MERGING EVIDENCE IN MEXICO: THE OPUS PRIME STUDY. Fanghänel-Salmón, Guillermo; Gutiérrez-Salmeán, Gabriela; Samaniego, Virginia; Meaney, Alejandra; Sánchez-Reyes, Leticia; Navarrete, Ulises; Alcocer, Luis; Olivares-Corichi, Ivonne; Najera, Nayeli; Ceballos, Guillermo; Meaney, Eduardo // Nutricion Hospitalaria;jul2015, Vol. 32 Issue 1, p182 

    Background and Aims: even though overweight and obesity (O/O) are stated diseases, there is still a claim for a so-called "healthy obese" phenotype. Only few reports have explored the presence of different metabolic phenotypes along the body mass index (BMI) range and their...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics