Visual Interactions Conform to Pattern Decorrelation in Multiple Cortical Areas

Sharifian, Fariba; Nurminen, Lauri; Vanni, Simo
July 2013
PLoS ONE;Jul2013, Vol. 8 Issue 7, p1
Academic Journal
Neural responses to visual stimuli are strongest in the classical receptive field, but they are also modulated by stimuli in a much wider region. In the primary visual cortex, physiological data and models suggest that such contextual modulation is mediated by recurrent interactions between cortical areas. Outside the primary visual cortex, imaging data has shown qualitatively similar interactions. However, whether the mechanisms underlying these effects are similar in different areas has remained unclear. Here, we found that the blood oxygenation level dependent (BOLD) signal spreads over considerable cortical distances in the primary visual cortex, further than the classical receptive field. This indicates that the synaptic activity induced by a given stimulus occurs in a surprisingly extensive network. Correspondingly, we found suppressive and facilitative interactions far from the maximum retinotopic response. Next, we characterized the relationship between contextual modulation and correlation between two spatial activation patterns. Regardless of the functional area or retinotopic eccentricity, higher correlation between the center and surround response patterns was associated with stronger suppressive interaction. In individual voxels, suppressive interaction was predominant when the center and surround stimuli produced BOLD signals with the same sign. Facilitative interaction dominated in the voxels with opposite BOLD signal signs. Our data was in unison with recently published cortical decorrelation model, and was validated against alternative models, separately in different eccentricities and functional areas. Our study provides evidence that spatial interactions among neural populations involve decorrelation of macroscopic neural activation patterns, and suggests that the basic design of the cerebral cortex houses a robust decorrelation mechanism for afferent synaptic input.


Related Articles

  • Investigating neurovascular coupling using canonical correlation analysis between pharmacological MRI and electrophysiology. Bießmann, Felix; Gretton, Arthur; Meinecke, Frank C.; Xiaoxhe Zhang; Rainer, Gregor; Logothetis, Nikos K.; Müller, Klaus-Robert; Rauch, Alexander // BMC Neuroscience;2009 Supplement 1, Vol. 10, Special section p1 

    Poster presentation Despite its young age, functional Magnetic Resonance Imaging (fMRI) has become one of the most popular brain imaging techniques. However, the relationship between brain activity and the blood oxygen level dependent (BOLD) contrast as measured with fMRI, the so called...

  • Realigning Thunder and Lightning: Temporal Adaptation to Spatiotemporally Distant Events. Navarra, Jordi; Fernández-Prieto, Irune; Garcia-Morera, Joel // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    The brain is able to realign asynchronous signals that approximately coincide in both space and time. Given that many experience-based links between visual and auditory stimuli are established in the absence of spatiotemporal proximity, we investigated whether or not temporal realignment arises...

  • Putting the Wnt in Synapses' Sails.  // BioWorld Today;4/2/2012, Vol. 23 Issue 63, Special section p2 

    The article discusses a study by a research team at the University of Utah which examined the role of the wnt pathway in the ability of the brain to adjust signaling strength.

  • Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease. Wilkinson, Kim; Khoury, Joseph El // International Journal of Alzheimer's Disease;2012, p1 

    Alzheimer's disease (AD) is increasing in prevalence with the aging population. Deposition of amyloid-β (Aβ) in the brain of AD patients is a hallmark of the disease and is associated with increased microglial numbers and activation state. The interaction of microglia with Aβ appears to...

  • health smarts. Brain Machine.  // PN;Jul2012, Vol. 66 Issue 7, p30 

    The article focuses on the technology discovered by Northwestern University researchers that can enable complex and voluntary movement of paralyzed hand, which has the potential to be tested on humans.

  • Cross interaction of melanocortinergic and dopaminergic systems in neural modulation. Zhi-Gang He; Bao-Wen Liu; Hong-Bing Xiang // International Journal of Physiology, Pathophysiology & Pharmacol;2015, Vol. 7 Issue 3, p152 

    Melanocortinergic and dopaminergic systems are widely distributed in the CNS and have been established as a crucial regulatory component in diverse physiological functions. The pharmacology of both melanocortinergic and dopaminergic systems including their individual receptors, signaling...

  • Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain. Morabito, Michael V.; Ravussin, Yann; Mueller, Bridget R.; Skowronski, Alicja A.; Watanabe, Kazuhisa; Foo, Kylie S.; Lee, Samuel X.; Lehmann, Anders; Hjorth, Stephan; Zeltser, Lori M.; LeDuc, Charles A.; Leibel, Rudolph L. // PLoS ONE;1/20/2017, Vol. 12 Issue 1, p1 

    Diet-induced obesity (DIO) resulting from consumption of a high fat diet (HFD) attenuates normal neuronal responses to leptin and may contribute to the metabolic defense of an acquired higher body weight in humans; the molecular bases for the persistence of this defense are unknown. We measured...

  • Graspable objects grab attention when the potential for action is recognized. Handy, Todd C.; Grafton, Scott T.; Shroff, Neha M.; Ketay, Sarah; Gazzaniga, Michael S. // Nature Neuroscience;Apr2003, Vol. 6 Issue 4, p421 

    Visually guided grasping movements require a rapid transformation of visual representations into object-specific motor programs. Here we report that graspable objects may facilitate these visuomotor transformations by automatically grabbing visual spatial attention. Human subjects viewed two...

  • The Role of GABAergic Inhibition in Ocular Dominance Plasticity. Heimel, J. Alexander; van Versendaal, Daniëlle; Levelt, Christiaan N. // Neural Plasticity;2011, Vol. 2011, Special section p1 

    During the last decade, we have gained much insight into the mechanisms that open and close a sensitive period of plasticity in the visual cortex. This brings the hope that novel treatments can be developed for brain injuries requiring renewed plasticity potential and neurodevelopmental brain...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics