TITLE

ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF INFLORESCENCE OF BORASSUS FLABELLIFER EXTRACTS ON STREPTOZOTOCIN INDUCED DIABETIC RATS

AUTHOR(S)
GOYAL, PRADEEP; MEEL, RAKESH KUMAR; SINGH, G. K.; NAGORI, B. P.
PUB. DATE
July 2013
SOURCE
Pharmanest;Jul/Aug2013, Vol. 4 Issue 4, p691
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The present study was aimed to evaluate the anti diabetic - activity potential of inflorescence of Borassus flabellifer extracts against streptozotocin (STZ) induced male wistar rats. Ethanolic extract of inflorescence of Borassus flabellifer was administered to streptozotocin induced male wistar rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of a dose of different extract of Borassus flabellifer (150, 300, 600 mg/kg b.wt) in diabetic groups. An ethanolic extract of Borassus flabellifer was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Borassus flabellifer on serum lipid profile like Total cholesterol, triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and high density lipoprotein (HDL) were also measured in the diabetic and non diabetic rats. There was significant reduction in Total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Borassus flabellifer possesses a hypoglycemic and antihyperlipidemic effect.
ACCESSION #
89524870

 

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