TITLE

Simultaneous Estimation Of Etodolac And Thiocolchicoside In Their Combined Marketed Formulation By RP-HPLC

AUTHOR(S)
Rathod, Kiran; Patel, Jitendra
PUB. DATE
October 2012
SOURCE
International Journal of PharmTech Research;Oct-Dec2012, Vol. 4 Issue 4, p1513
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A reversed-phase-liquid chromatographic (RP-HPLC) method was developed for the simultaneous estimation of Etodolac and Thiocolchicoside in their combinedtablet dosage form. The method was carried out on a PhenomenexC-18 column (250 mm × 4.60 mm i.d., particle size 5 μm), with a mobile phase consisting of methanol and phosphate buffer pH 6, (85:15 v/v) at flow rate 0.8 ml/ min. The wavelength used for detection of Etodolac and Thiocolchicoside was 259 nm. The retention time of Etodolac and Thiocolchicoside were found to be 4.39±0.10 min. and 3.52±0.10 min. respectively. The method was validated in terms of linearity, range, accuracy, precision, limit of detection (LOD) and limit of quantitation (LOQ) as per ICH guidelines. The method showed a good linearity in the concentration range of 16-96 μg/ml for Etodolac and 4-24 μg/ml for Thiocolchicoside. The % recoveries of Etodolac and Thiocolchicosidewere found to be between 99.90-101.08% and 99.75-99.98% respectively.The %RSD for the method precision was found to be less than 2%.The proposed method can be successfully applied for the simultaneous estimation of Etodolac and Thiocolchicoside in combined tablet dosage form.
ACCESSION #
89250741

 

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