April 2013
International Journal of Pharmacy & Pharmaceutical Sciences;2013 Supplement 2, Vol. 5, p116
Academic Journal
Objective: Antiasthmatic activity of aqueous extract of Pistacia integerrima galls in various experimental models. Methods: The mast cell stabilization, antihistaminic and spasmolytic activity of aqueous extract of galls was evaluated using albino Wistar rats and guinea pigs. The effect on mast cell stabilization was performed by ex vivo challenge of antigen in sensitized rat intestinal mesenteries. Antihistaminic activity was studied in guinea pigs using histamine-induced bronchospasm where preconvulsive dyspnea (PCD), was used as an end point following exposure to histamine aerosol and spasmolytic activity was studied on isolated guinea pig tracheal chain preparation where percentage inhibition in histamine induced contraction was measured. Results: Treatment with aqueous extract of galls showed a dose dependent effect on disruption rate of actively sensitized mesenteric mast cells of albino rats when challenged with antigen (horse serum along with triple antigen vaccine).Aqueous extract of galls treatment for ten days resulted in significant protection against histamine aerosol-induced bronchospasm in guinea pigs and showed the spasmolytic activity against histamine induced contractions in isolated guinea pig tracheal chain preparation. Conclusion: Antiasthmatic activity extract galls may be due to the membrane stabilizing potential, suppression of antibody production and inhibition of antigen induced histamine release.


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