Phacomatosis Pigmentokeratotica Is a 'Pseudodidymosis'

Happle, Rudolf
August 2013
Journal of Investigative Dermatology;Aug2013, Vol. 133 Issue 8, p1923
Academic Journal
In phacomatosis pigmentokeratotica, papular nevus spilus coexists with nevus sebaceus. The disorder was thought to be a didymosis with early postzygotic recombination. In this issue, however, Groesser and co-workers provide a new concept. Both nevi originate from a single heterozygous HRAS mutation in a pluripotent progenitor cell. This new understanding has implications for other proposed examples of didymosis in humans.


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