TITLE

ACINETOBACTER SPP. SKIN AND SOFT TISSUE INFECTIONS IN THE CLINICAL INFECTIOUS DISEASES HOSPITAL OF IAÅžI CITY, BETWEEN 2006 AND 2010

AUTHOR(S)
Vâţă, D.; Olga, Filip; Olivia, Dorneanu; Cătălina, Luca; Carmen, Manciuc; Carmen, Dorobăt; Laura, Solovăstru; Vâţă, A.
PUB. DATE
June 2012
SOURCE
Therapeutics, Pharmacology & Clinical Toxicology;Jun2012, Vol. 16 Issue 2, p95
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Acinetobacter (ACB) species have often revealed themselves as highly resistant to antibiotics, occurring preponderantly in vulnerable patients and sometimes causing severe infections, which are difficult to treat. Material and method: retrospective study on patients diagnosed in the Clinical Infectious Diseases Hospital of Iasi City, between January 2006 and December 2010; the demographic, clinical and microbiological characteristics of patients suffering from skin and soft tissue (SST) infections caused by ACB were compared to those of other patients with different infection locations. Results: 24.4% of the whole 45 ACB strains isolated throughout the study were involved in SST infections. Most of them (10/11) had a significant number of associated conditions; average age - 59.4 years, preponderantly males (63.6%). The most frequent isolate was Acinetobacter baumanni (8/11 cases, 4 of whom also had bacteremia). The isolated strains were resistant to multiple classes of antibiotics (anti-pseudomonas cephalosporins - 8/11, imipenem 6/11, amikacin 6/9, and ciprofloxacin 8/10); colistin was the only antibiotic that revealed good anti-ACB activity, as only one of its strains was antibiotic resistant. Multidrug-resistance was noticed in 4/11 strains. ACB SST infections were lethal in 9.1% of the cases. There were no statistically significant differences between the demographic, epidemiological or antibiotic-resistance variables of patients with SST infections and those of other patients with different ACB infection locations. Conclusions: the ACB infection located on SST distinguishes itself by its severity and serious therapeutic challenges, whereas its antibiotic-resistance behavior is similar to that of infections with different locations.
ACCESSION #
88990591

 

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