Mast cells in infantile haemangioma possess a primitive myeloid phenotype

Itinteang, Tinte; Tan, Swee T.; Jia, Jun; Steel, Ryan; Laing, Emma L.; Brasch, Helen D.; Day, Darren J.
July 2013
Journal of Clinical Pathology;Jul2013, Vol. 66 Issue 7, p597
Academic Journal
Aims Recent reports on infantile haemangioma (IH) have demonstrated a primitive population of interstitial cells expressing the embryonic transcription factor, Nanog, with decreasing abundance during involution. In this report we investigated the expression of Nanog on mast cells in all three phases of IH progression. Methods Paraffin-embedded sections of six proliferating, six involuting and six involuted IH lesions were used to investigate the expression of tryptase, Nanog, CD45, CD34 and GLUT-1 by immunostaining. Results Mast cells, identified by their expression of tryptase, were located in the interstitium of IH lesions. 93%, 42% and 0% of these tryptase+ cells also expressed Nanog, in proliferating, involuting and involuted IH, respectively. Conclusions The identification of an abundant population of tryptase+/Nanog+ cells in IH is novel. The relative loss of Nanog expression as IH involutes may be a result of maturation and/or proliferation of these cells. This report supports the primitive nature of IH.


Related Articles

  • Mast cells: Distal signalling in mast cell degranulation. Papatriantafyllou, Maria // Nature Reviews Immunology;Jun2013, Vol. 13 Issue 6, p393 

    The article reports on the findings of the study that determines the role of truncated splice variant of the FcƐRI ß-subunit in mast cell degranulation.

  • Mast cells in the human dura: effects of age and dural bleeding. Greeley, Christopher; Karst, Wouter // Child's Nervous System;Nov2013, Vol. 29 Issue 11, p1967 

    A letter to the editor is presented in response to the article "Mast cells in the human dura: effects of age and dural bleeding" by A. Varatharaj and colleagues in the September 7, 2013 issue.

  • Most hemangioma growth occurs in the first few weeks or months of life. Stephenson, Michelle // Infectious Diseases in Children;Sep2008, Vol. 21 Issue 9, p19 

    The article discusses research on the growth of infantile hemangioma. It references a study by L. C. Chang et al published in a 2008 issue of "Pediatrics." According to the study, majority of hemangioma in infants grow within five months of life. The study found that the patients were referred...

  • Isolation and Cultivation of Human Testicular Peritubular Cells. Mayerhofer, Artur // Fertility Weekly;9/4/2006, p2 

    The article discusses on the cultivation and isolation of human testicular peritubular cells as a convenient model in the study of adult human peritubular cells. It was stated that the testes of infertile patients often exhibit fibrotic thickening of the peritubular area and corresponds with...

  • A Molecular Understanding of Mast Cell Activation and the Promise of Anti- Allergic Therapeutics. Kovarova, Martina; Rivera, Juan // Current Medicinal Chemistry;Aug2004, Vol. 11 Issue 15, p2083 

    Mast cells are central to allergic disease. Their immediate (exocytosis of granule-stored allergicmediators) and delayed (de novo synthesis of inflammatory mediators) response to an allergen underlies the symptoms seen in acute and chronic allergic disease. Thus, intervention in the...

  • Photoelectric Method for Quantitative Evaluation of Mast-Cell-Associated Enzyme Activity in Human Gingival Tissues. SORENSON, F. M.; BENNETT, J. S.; FUJITA, D.; POINDEXTER, F. R.; HALL, W. B. // Journal of Dental Research;May1970, Vol. 49 Issue 3, p480 

    Simple counts of mast cells per unit of human gingiva are often difficult to interpret because of the large numbers and varying sizes and shapes of the counted structures. The relatively simple photoelectric scanning method described herein eliminates tedious counting procedures while providing...

  • Quercetin Is More Effective than Cromolyn in Blocking Human Mast Cell Cytokine Release and Inhibits Contact Dermatitis and Photosensitivity in Humans. Zuyi Weng; Zhang, Bodi; Asadi, Shahrzad; Sismanopoulos, Nikolaos; Butcher, Alan; Xueyan Fu; Katsarou-Katsari, Alexandra; Antoniou, Christina; Theoharides, Theoharis C. // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Mast cells are immune cells critical in the pathogenesis of allergic, but also inflammatory and autoimmune diseases through release of many pro-inflammatory cytokines such as IL-8 and TNF. Contact dermatitis and photosensitivity are skin conditions that involve non-immune triggers such as...

  • More Activated Mast Cells are Present in Endometriotic Lesions Positive for CRH/Ucn.  // Fertility Weekly;2/7/2005, p7 

    The article cites a study by researchers D. Kempuraj and colleagues, which reports that the number of mast cells is increased in peritoneal endometriotic tissue. The researchers found these cells to be highly activated and present at sites strongly positive for corticotropin-releasing hormone...

  • Non-infiltrating angiolipoma of the upper lip: A rare entity. Sah, Kunal; Kadam, Ajit; D., Sunita J.; Chandra, Sunira // Journal of Oral & Maxillofacial Pathology (0973029X);Jan2012, Vol. 16 Issue 1, p103 

    Angiolipoma is a variant of lipoma with a prominent vascular component. It is the most common tumor of the forearm followed by trunk and extremities of young individuals. It's occurrence in head and neck region is rare. In this report, we present clinical and histopathologic features of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics