TITLE

Anti-arthritic activity of Tribulus terrestris studied in Freund's Adjuvant induced arthritic rats

AUTHOR(S)
Mishra, N. K.; Biswal, G. S.; Chowdary, K. A.; Mishra, G.
PUB. DATE
June 2013
SOURCE
Journal of Pharmaceutical Education & Research;Jun2013, Vol. 4 Issue 1, p41
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the present study, methanolic extract of Tribulus terrestris fruit was assessed for anti-arthritic activity in rat. The anti-arthritic activity of Tribulus terrestris (200mg/kg and 300 mg/kg p.o) was evaluated using Frund's complete adjuvant (FCA) induced arthritis in rats. The herbal extracts at dose 200mg/kg and 300 mg/kg p.o was administered for 21 days after the injection of FCA in the rats paws. A significant (P = 0.01) inhibition of paw edema volume was observed from day 5th to 21st in the treated groups. The biochemical parameters like erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), acid phospatase (ACP) and total WBC count was observed which are the major markers of arthritis. A significant increase in the level of all the markers were found in the arthritic rats where as in case of prednisolan and Tribulus terrestris (200mg/kg and 300 mg/kg) treated groups a marked decrease in the level was observed. A better anti-arthritic activity was obtained at 300 mg/kg dose of Tribulus terrestris. These results indicate that the methanolic extact of Tribulus terrestris has anti-arthritic activity.
ACCESSION #
88925380

 

Related Articles

  • Anti-hyperglycaemic Activity of Tribulus terrestris L Aerial Part Extract in Glucose-loaded Normal Rabbits. El-Shaibany, Amina; AL-Habori, Molham; Al-Tahami, Belqes; Al-Massarani, Shaza // Tropical Journal of Pharmaceutical Research;Dec2015, Vol. 14 Issue 12, p2263 

    Purpose: To investigate the anti-hyperglycaemic activity of methanol extract of Tribulus terrestris L. Zygophyllaceae in glucose-loaded normal rabbits. Methods: The animals were randomly assigned to 4 groups (n = 5) and treated with a single oral dose. Group 1 served as normal control group and...

  • EVALUATION OF THE CYTOKINES PATTERN IN AN ANIMAL MODEL OF RHEUMATOID ARTHRITIS. Domínguez, M. C.; Del Barco, D. García; Taylor, C.; Urquiza, D.; Rodríguez, D.; Suárez, J.; Vázquez, A.; Merino, N.; Cosme, K.; Padrón, G. // Revista VacciMonitor (Vacunología y Temas Afines);Oct2002, Vol. 11 Issue 4, p1 

    Recent advances in our understanding of cellular and molecular mechanisms of Rheumatoid Arthritis (RA) have highlighted a critical role for th1 cytokines. Adjuvant arthritis (AA) is an experimental model of RA that can be induced in susceptible inbred strains of rats upon immunization with...

  • Design, expression and characterization of a novel coexpression system of two antiarthritic molecules. Zhang, Wei; Wang, Fang; Yan, Jinqi; Zhang, Xiaojun; Wang, Yu; Jiang, Yunbo; Wang, Lin; Xu, Yuanji; Yu, Jiyun // Applied Microbiology & Biotechnology;Jul2013, Vol. 97 Issue 14, p6301 

    The complexity of rheumatoid arthritis (RA) pathogenesis makes combined blockade of multiple targets an attractive therapeutic strategy. The combination therapy with anti-TNF plus anti-T-cell has been mostly reported to provide greater efficacy than anti-TNF alone. TNFR (p75)-Fc fusion protein,...

  • Antiarthritic and antioxidant effects of the leaf extract of Ficus exasperata P. Beauv. (Moraceae). Abotsi, Wonder M. K.; Woode, Eric; Ainooson, George K.; Amo-Barimah, Ama K.; Boakye-Gyasi, Eric // Pharmacognosy Research;Mar2010, Vol. 2 Issue 2, p89 

    Leaf extracts of Ficus exasperata P. Beauv. (Moraceae) are commonly used in Ghanaian traditional medicine for the treatment of several pathological states including inflammatory disorders. The present study was undertaken to evaluate the antiarthritic effect of an ethanolic extract of F....

  • SKLB023 Blocks Joint Inflammation and Cartilage Destruction in Arthritis Models via Suppression of Nuclear Factor-Kappa B Activation in Macrophage. Xie, Caifeng; Ma, Liang; Liu, Juan; Li, Xiuxia; Pei, Heying; Xiang, Mingli; Chen, Lijuan // PLoS ONE;Feb2013, Vol. 8 Issue 2, p1 

    Rheumatoid arthritis (RA) is the most common arthritis and is mainly characterized by symmetric polyarticular joint disorders. Our previous study demonstrated a novel small molecule compound (Z)-N-(3-Chlorophenyl)-2-(4-((2,4-dioxothiazolidin-5-ylidene) methyl) phenoxy) acet-amide (SKLB023)...

  • Comparison between penicillamine and sulphasalazine in rheumatoid arthritis: Leeds-Birmingham trial. Neumann, V.C.; Grindulis, K.A.; Hubball, S.; McConkey, B.; Wright, V. // British Medical Journal (Clinical Research Edition);10/15/1983, Vol. 287 Issue 6399, p1099 

    Compares the efficacy of penicillamine and sulphasalazine in treating rheumatoid arthritis. Capabilities of Sulphasalazine in producing remissions; Precautions on the intake of the drugs; Concerns on the side effects of penicillamine.

  • Auranofin or D-Penicillamine in the Treatment of Rheumatoid Arthritis. Hochberg, Marc C. // Annals of Internal Medicine;Oct86, Vol. 105 Issue 4, p528 

    Presents a study which compared the effectiveness of auranofin and d-penicillamine in the treatment of rheumatoid arthritis. Patients and methods; Results; Discussion.

  • Celecoxib has a better cardiorenal profile than diclofenac/ibuprofen.  // Reactions Weekly;11/11/2006, Issue 1127, p1 

    The article discusses research being done on the cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen. It references a study by A. Whelton et al published in the October 2006 issue of "Kidney International" journal. The study found...

  • ANTI-INFLAMMATORY AND ANTIARTHRITIC POTENTIAL OF AMMANIA BACCIFERA LINN. Tripathy, S.; Pradhan, D.; Anjana, M. // International Journal of Pharma & Bio Sciences;Jul-Sep2010, Vol. 1 Issue 3, p1 

    The anti arthritic potential of Ammania baccifera Linn (Lythraceae) extracts were evaluated by taking chronic inflammatory models like cotton pallet induced granuloma and complete Freund's Adjuvant (CFA)induced arthritis in albino rats. Arthritis was induced by injecting 0.1ml of complete...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics