Anti-arthritic activity of Tribulus terrestris studied in Freund's Adjuvant induced arthritic rats

Mishra, N. K.; Biswal, G. S.; Chowdary, K. A.; Mishra, G.
June 2013
Journal of Pharmaceutical Education & Research;Jun2013, Vol. 4 Issue 1, p41
Academic Journal
In the present study, methanolic extract of Tribulus terrestris fruit was assessed for anti-arthritic activity in rat. The anti-arthritic activity of Tribulus terrestris (200mg/kg and 300 mg/kg p.o) was evaluated using Frund's complete adjuvant (FCA) induced arthritis in rats. The herbal extracts at dose 200mg/kg and 300 mg/kg p.o was administered for 21 days after the injection of FCA in the rats paws. A significant (P = 0.01) inhibition of paw edema volume was observed from day 5th to 21st in the treated groups. The biochemical parameters like erythrocyte sedimentation rate (ESR), alkaline phosphatase (ALP), acid phospatase (ACP) and total WBC count was observed which are the major markers of arthritis. A significant increase in the level of all the markers were found in the arthritic rats where as in case of prednisolan and Tribulus terrestris (200mg/kg and 300 mg/kg) treated groups a marked decrease in the level was observed. A better anti-arthritic activity was obtained at 300 mg/kg dose of Tribulus terrestris. These results indicate that the methanolic extact of Tribulus terrestris has anti-arthritic activity.


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