SILVA-PINTO, André; SANTOS, Maria Lurdes
December 2011
Acta Medica Portuguesa;SUP2011, Vol. 24 Issue S4, p923
Academic Journal
Despite being uncommon, there is a small group of HIV infected that, even without treatment, do not evolve to AIDS. Several theories have been proposed over time trying to explain this phenomenon. This article addresses the role of HLA in the TC modulation. Objectives - Review the literature about the role of MHC in the progression of HIV infection and identify which HLA has a greater role in the progression of HIV infection. Methods-- There were included 24 original articles (19 per bibliographic search, four for cross reference and one by a survey of recently published articles) Development - Unlike humans, chimpanzees can prevent the progression of HIV disease. Their HLA has also a greater similarity with the HLA of LTNP. These phenotypes of progression of infection are the result of a combination of protective and progressive factors. Among the protective factors are HLA class I molecules, especially HLA-B. Several studies have been published on this subject and showed that the main HLA not involved in the progression of the HIV infection are HLA B27 and B57. A study recently published was able to show that variations in specific amino acids have been associated with the management of HIV infection. Conclusion - It is now thought that the major genetic factor capable of modulating the progression of HIV infection is the HLA-peptide interaction and more research is needed so that knowledge can be used to support the treatment of patients infected with HIV infection


Related Articles

  • Molecular Mimicry in HLA--B27--Related Arthritis. Yu, David T.Y.; Choo, S. Yoon; Schaack, Terry // Annals of Internal Medicine;10/1/89, Vol. 111 Issue 7, p581 

    Discusses the molecular structure of HLA-b27-related arthritis. Hypotheses on the pathogenesis of arthritis; Structure of HLA-b27 molecules; Identification of mimicking bacterial components; Prediction of immune reactivity from the primary structure of the proteins.

  • How to Bring Elite Controller Status to the Huddled Masses. Breindl, Anette // BioWorld Today;5/6/2010, Vol. 21 Issue 87, p1 

    This article discusses a study on human immunodeficiency virus (HIV)-positive persons whose diseases did not progress to acquired immunodeficiency syndrome (AIDS) in the absence of treatment. The study found variants of human leukocyte antigen (HLA) molecules in patients with HIV infections. It...

  • Abstracts from global literature: Role of genetic factors in human immunodeficiency virus progression. Marfatia, Zarna; Pandya, Ipsa // Indian Journal of Sexually Transmitted Diseases;Jan-Jun2014, Vol. 35 Issue 1, p65 

    The article presents abstracts on medical topics which include the association of human leukocyte antigen with early plasma viral load, the correlation of tumor necrosis factor c2 with the progression of human immunodeficiency virus, and the reduced mortality in HIV-positive people.

  • Ankylosing Spondylitis, HLA-B27, Klebsiella and "Popper Sequences.". Ebringer, Alan; Rashid, Taha; Fielder, Mark; Wilson, Clyde // Current Rheumatology Reviews;2011, Vol. 7 Issue 4, p322 

    The cause of ankylosing spondylitis (AS) was investigated through 11 Karl Popper sequences. "Popper sequences" provide a powerful method of investigating a scientific problem. A "Popper sequence" consists of a "problem", "tentative theory", "error elimination" which then leads to a "new fact"....

  • HLA-B27 a three-decade quest. Charters, Lynda // Ophthalmology Times;8/1/2011, Vol. 36 Issue 15, p22 

    The article examines the secrets on human leukocyte antigen B27 (HLA-B27) and its connection with ankylosing spondylitis. It notes that HLA-B27 changes microbiome suggesting that an individual is inclined to ankylosing spondylitis, reactive arthritis, and acute anterior uveitis. It also...

  • Immunoradiometric assay for the rapid detection of HLA-B27. Trapani, Joseph A.; Vaughan, Hilary A.; Tait, Brian D.; Mckenzie, Ian F. C. // Immunology & Cell Biology;Jun1988, Vol. 66 Issue 3, p215 

    A new method for the rapid detection of the HLA-B27 antigen is discussed which consists of a direct immunoradiometric assay (IRA) utilizing a 125I-labelled. HLA-B27 specific monoclonal antibody to detect HLA-B27 in whole citrated blood. Thus far, the assay has been used to assign HLA-B27 status...

  • The ramifications of HLA-B27. Sheehan, Nicholas J. // Journal of the Royal Society of Medicine;Jan2004, Vol. 97 Issue 1, p10 

    The article focuses on HLA-B27 and its evolution over the years. It has been noted that the link between HLA-B27 and ankylosing spondylitis was considered the strongest proof between a major histocompatibility complex antigen and a disease. A European population study found that there is a...

  • HUMAN LEUKOCYTE ANTIGEN B27  // Davis's Comprehensive Handbook of Laboratory & Diagnostic Tests ;Jan2006, p778 

    The human leukocyte antigens (HLAs) are gene products of the major histocompatibility complex, derived from their respective loci on the short arm of chromosome 6. There are more than 27 identified HLAs. HLA-B27 is an allele (one of two or more genes for an inheritable trait that occupy the same...

  • HUMAN LEUKOCYTE ANTIGEN B27. Schnell, Zoanne Burgess; Van Leeuwen, Anne M.; Kranpitz, Todd R. // Davis's Comprehensive Handbook of Laboratory & Diagnostic Tests ;Jan2003, p601 

    Presents a comprehensive guide to laboratory and diagnostic tests for human leukocyte antigen B27. Specimen collection; Description of the purpose of the study and insight into how and why the test results can affect health; Use of the test in terms of assessment, evaluation and assisting in the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics