Epidemiological changes in rotavirus gastroenteritis in children under 5 years of age after the introduction of rotavirus vaccines in Korea

Choi, Ui; Lee, Soo; Ma, Sang; Jang, Young; Kim, Jae; Kim, Hwang; Kim, Jong; Kim, Dong; Kim, Yong; Kang, Jin
July 2013
European Journal of Pediatrics;Jul2013, Vol. 172 Issue 7, p947
Academic Journal
Rotavirus gastroenteritis is the leading cause of severe acute gastroenteritis in children worldwide and is associated with high hospitalization and mortality rates in children younger than 5 years of age. Vaccination is necessary to prevent rotavirus infection. Two live attenuated and orally administered rotavirus vaccines became commercially available in Korea. The aim of this study is to describe epidemiological changes in rotavirus gastroenteritis after the introduction of rotavirus vaccines in Korea. The medical records of 11,199 children younger than 5 years of age and hospitalized for acute gastroenteritis from August 2007 to July 2010 in eight Korean hospitals were reviewed. Rotavirus was detected in stool samples obtained from 2,959 children (26.42 %). The authors evaluated the percentage of rotavirus gastroenteritis among all acute gastroenteritis hospitalizations in eight hospitals located in different geographical areas and analyzed epidemiological changes in rotavirus gastroenteritis according to age, geographical area, and season. According to the findings, the percentage of rotavirus gastroenteritis showed a decrease in children eligible for vaccination during the study period. After introduction of the vaccine, reduced rates of rotavirus detection were observed in all of the geographical areas, and the greatest reduction was observed in Seoul. In Seoul, there was a marked delay of the rotavirus season. Conclusion: Epidemiologic changes in Korea after the introduction of rotavirus vaccine are consistent with changes observed in other countries.


Related Articles

  • Acute Gastroenteritis in a Pediatric Hospital in Rio de Janeiro in Pre- and Post-Rotavirus Vaccination Settings. Gouvea, Vera S.; Dias, Giselly S.; Aguiar, Ericka A.; Pedro, Adriana R.; Fichman, Elisa R.; Chinem, Evelyn S.; Gomes, Sandra P.; Domingues, André L. S. // Open Virology Journal;2009, Vol. 3, p26 

    A 4½-year hospital-based survey was conducted in Rio de Janeiro to determine baseline rates of gastroenteritisrelated cases, hospitalizations, and deaths; to examine the prevalence of rotavirus strains causing admissions; and to assess the immediate impact of the nationwide rotavirus...

  • Effectiveness of Pentavalent and Monovalent Rotavirus Vaccines in Concurrent Use Among US Children <5 Years of Age, 2009–2011. Payne, Daniel C.; Boom, Julie A.; Staat, Mary Allen; Edwards, Kathryn M.; Szilagyi, Peter G.; Klein, Eileen J.; Selvarangan, Rangaraj; Azimi, Parvin H.; Harrison, Christopher; Moffatt, Mary; Johnston, Samantha H.; Sahni, Leila C.; Baker, Carol J.; Rench, Marcia A.; Donauer, Stephanie; McNeal, Monica; Chappell, James; Weinberg, Geoffrey A.; Tasslimi, Azadeh; Tate, Jacqueline E. // Clinical Infectious Diseases;Jul2013, Vol. 57 Issue 1, p13 

    Using a large, pediatric active surveillance network throughout the United States, both licensed and concurrently used rotavirus vaccines significantly protected against medically attended rotavirus gastroenteritis. Vaccine performance appeared to neither diminish over time, nor differ by...

  • Characteristics of Rotavirus Diarrhea in Hospitalized Children in Kosovo. Ismaili-Jaha, Vlora; Shala, Muje; Azemi, Mehmedali; Hoxha-Kamberi, Teuta; Avdiu, Muharrem; Spahiu, Shqipe; Jaha, Luan // Materia Socio Medica;Oct2014, Vol. 26 Issue 5, p335 

    Background: Diarrhea is a leading cause of child mortality worldwide. Rotavirus is one of the most common causes of severe diarrhea and dehydration in children. Authors reviewed epidemiological and clinical data of the rotavirus diarrhea in Kosovo. Methods: This is a prospective study carried...

  • Vaccine Epidemiology: Efficacy, Effectiveness, and the Translational Research Roadmap. Weinberg, Geoffrey A.; Szilagyi, Peter G. // Journal of Infectious Diseases;6/1/2010, Vol. 201 Issue 11, p1607 

    In this article the authors discuss the study of Aaron T. Curns and colleagues on the efficacy of using pentavalent rotavirus vaccine for acute gastroenteritis among children in the U.S. It highlights the benefits of vaccine efficacy and effectiveness and the distinction between their...

  • Economic Costs of Rotavirus Gastroenteritis and Cost-Effectiveness of Vaccination in Developing Countries. Rheingans, Richard D.; Antil, Lynn; Dreibelbis, Robert; Podewils, Laura Jean; Bresee, Joseph S.; Parashar, Umesh D. // Journal of Infectious Diseases;11/2/2009, Vol. 200 Issue S1, pS16 

    Background. Rotavirus is the leading cause of severe gastroenteritis in children worldwide. We evaluated the economic burden of rotavirus and the cost-effectiveness of vaccination from the health care perspective. Methods. Estimates were based on existing epidemiological data, cost estimates,...

  • Epidemiology and prospects for prevention of rotavirus disease in India. Kahn, G.; Fitzwater, S.; Tate, J.; Kang, G.; Ganguly, N.; Nair, G.; Steele, D.; Arora, R.; Chawlasarkar, M.; Parashar, U.; Santosham, M. // Indian Pediatrics;Jun2012, Vol. 49 Issue 6, p467 

    Context: With rotavirus vaccines now available globally, it will be useful to assemble the available evidence on the epidemiology and burden of rotavirus gastroenteritis in India, in order to weigh the urgency of introducing a vaccine to help control rotavirus disease. Evidence Acquisition: We...

  • All-Cause Gastroenteritis and Rotavirus-Coded Hospitalizations Among US Children, 2000–2009. Desai, Rishi; Curns, Aaron T.; Steiner, Claudia A.; Tate, Jacqueline E.; Patel, Manish M.; Parashar, Umesh D. // Clinical Infectious Diseases;8/15/2012, Vol. 55 Issue 4, pe28 

    Since the approval of rotavirus vaccine in 2006 for routine use in US children, there has been a marked reduction in the number of and direct medical charges for all-cause gastroenteritis hospitalizations and rotavirus-coded hospitalizations.Background. Rotavirus vaccine was recommended for US...

  • Fiebre manchada de las Montañas Rocosas en niños: experiencia hospitalaria. Gómez Rivera, Norberto; Álvarez Hernández, Gerardo; Guadalupe García Zárate, María; Fonseca Chon, Ignacio; Villalobos García, Luis; Cano Rangel, Manuel Alberto // Revista Mexicana de Pediatria;Nov/Dec2013, Vol. 80 Issue 6, p227 

    Objective: Highlight the epidemiological and clinical importance derived from the lab tests state of Rocky Mountain spotted fever (RMSF) in children who were cared for in the children's hospital in Sonora. Material and methods: We reviewed the clinical records of 116 children with RMSF admitted...

  • Reduction in Acute Gastroenteritis Hospitalizations among US Children After Introduction of Rotavirus Vaccine: Analysis of Hospital Discharge Data from 18 US States. Curns, Aaron T.; Steiner, Claudia A.; Barrett, Marguerite; Hunter, Katherine; Wilson, Emily; Parashar, Umesh D. // Journal of Infectious Diseases;6/1/2010, Vol. 201 Issue 11, p1617 

    Background. In 2006, RotaTeq (RV5) was recommended for routine vaccination of United States (US) infants. We compared hospitalization rates for acute gastroenteritis among US children aged <5 years during pre-RV5 rotavirus seasons from 2000 through 2006 with those during the post-RV5 2007 and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics