Arterial blood oxygenation, maximum exercise capacity and oxygen transport in patients before and after autologous peripheral blood progenitor cell transplantation

Gruber, A; Brundin, T; Björkholm, M
July 1999
Bone Marrow Transplantation;7/15/99, Vol. 24 Issue 2, p169
Academic Journal
Several studies have reported a reduced pulmonary diffusion capacity for carbon monoxide after total body irradiation (TBI) and/or high-dose chemotherapy (HDCT) and autologous peripheral blood progenitor transplantation (APBPC). The present study describes the oxygenation of arterial plasma (paO2), the maximum exercise capacity (Wmax) and maximum oxygen transport (VO2max) before and after such treatment. Pulmonary gas exchange and paO2 were measured in 15 patients at maximum dynamic bicycle exercise, performed before and at 8 ± 0.9 (s.e.m.) months after TBI/HDCT (n = 12) and HDCT (n = 3) followed by APBPC. Wmax was 169 ± 14 and 157 ± 15 watts (P > 0.05) before and after therapy, respectively. VO2max, 1.8 ± 0.1 l/min before treatment, fell to 1.6 ± 0.1 l/min (P < 0.05) after therapy. the maximum exercise pao2 was 13.2 ± 0.4 kPa before and 13.6 ± 0.4 kPa (P > 0.05) after the treatment period. The findings indicate no significant reduction of Wmax or pulmonary diffusion capacity for O2 after TBI/HDCT and APBPC while VO2max fell modestly by approximately 11%. The study was restricted to patients who remained in remission.


Related Articles

  • Quality assessment of autologous haematopoietic blood progenitor cell grafting. Lanza, Francesco; Dallorso, Sandro; Milone, Giuseppe; Spedini, Pierangelo; Viganò, Clara; Johnsen, Hans // Annals of Hematology;Apr2015, Vol. 94 Issue 4, p705 

    A letter to the editor is presented in response to the article "Factors predicting haematopoietic recovery in patients undergoing autologous transplantation: 11-year experience from a single centre" by L. Bai and others in a 2014 issue.

  • Hematopoietic stem cell transplantation in hematologic malignancies and solid tumors: Hacettepe University Institute of Oncology experience. Oyan, Basak; Koc, Yener; Kars, Ayse; Turker, Alev; Akyuz, Canan; Guc, Dicle; Uner, Aysegul; Ruacan, Sevket; Yigitbas, Emre; Canpinar, Hande; Tekin, Fatma; Topcu, Pakize; Karakaya, Fikriye; Zorlu, Faruk; Ozyar, Enis; Kocal, Nursel; Rakunt, Gul; Cil, Barbaros; Cetinkaya, Yeslim // Turkish Journal of Cancer;Jan2003, Vol. 33 Issue 1, p27 

    Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) have emerged as a frequently used treatment modality in patients with hematologic malignancies and selected solid tumors. Hematopoietic Stem Cell Unit of Hacettepe University Institute of Oncology is recetly inaugurated and...

  • Ideal or actual body weight to calculate CD34+ cell doses for autologous hematopoietic stem cell transplantation? Ali, M Y; Oyama, Y; Monreal, J; Winter, J N; Tallman, M S; Williams, S F; Singhal, S; Gordon, L I; Mehta, J // Bone Marrow Transplantation;May2003, Vol. 31 Issue 10, p861 

    Summary:The number of CD34+ cells infused influences the speed of hematologic recovery post-transplant. There are limited data on whether ideal (IBW) or actual (ABW) body weight should be used to calculate CD34+ cell dose. We compared the correlation between recovery to 0.5 x 109/l neutrophils...

  • 24. Infections (bacterial / fungal).  // Bone Marrow Transplantation;3/2/2002 Supplement, Vol. 29 Issue 5, pS240 

    Bone Marrow Transplantation (2001) 29, Suppl. 2, S240–S249. DOI: 10.1038/sj/bmt/1703493

  • Shortening of telomeres in recipients of both autologous and allogeneic hematopoietic stem cell transplantation. Akiyama, M; Asai, O; Kuraishi, Y; Urashima, M; Hoshi, Y; Sakamaki, H; Yabe, H; Furukawa, T; Yamada, O; Mizoguchi, H; Yamada, H // Bone Marrow Transplantation;2/15/2000, Vol. 25 Issue 4, p441 

    Telomere length of peripheral blood mononuclear cells (PBMCs) from 23 autologous HSCT patients ranging from 4 to 61 years old, and 46 allogeneic HSCT recipients from 6 to 52 years old were studied to confirm whether excessive shortening of telomeres is associated with HSCT. After autologous...

  • Should involved-field radiation therapy be used as an adjunct to lymphoma autotransplantation? Wadhwa, P.; Schenkein, D.C.; Lazarus, H.M. // Bone Marrow Transplantation;2/1/2002, Vol. 29 Issue 3, p183 

    Discusses a review which addressed the rationale for using involved-field radiation therapy in the autologous hematopoietic stem cell transplant setting. Review of literature on the treatment modality; Potential toxicity and concerns regarding the procedure; Conclusions.

  • Outcomes of allogeneic hematopoietic stem cell transplantation for lymphomas: a single-institution experience. Massoud, Mira Romany; Caimi, Paolo Fabrizio; Ferrari, Nicole; Pingfu Fu; Creger, Richard; Fox, Robert; Carlson-Barko, Joanne; Kolk, Merle; Brister, Lauren; Cooper, Brenda Wimpfheimer; Gerson, Stanton; Lazarus, Hillard Michael; de Lima, Marcos; William, Basem Magdy // Revista Brasileira de Hematologia e Hemoterapia;out-dez2016, Vol. 38 Issue 4, p314 

    Introduction: Allogeneic hematopoietic stem cell transplantation offers the opportunity for extended survival in patients with Hodgkin's and non-Hodgkin lymphomas who relapsed after, or were deemed ineligible for, autologous transplantation. This study reports the cumulative experience of a...

  • Allogeneic peripheral blood progenitor cells for treatment of relapse after bone marrow transplantation. Glass, B; Majolino, I; Dreger, P; Scimè, R; Santoro, A; Vasta, S; Suttorp, M; Haferlach, T; Schmitz, N // Bone Marrow Transplantation;10/1/97, Vol. 20 Issue 7, p533 

    Donor leukocyte infusions (DLI) are an effective therapy for patients who relapse with leukemia after bone marrow transplantation (BMT). Severe graft-versus-host disease and prolonged periods of pancytopenia compromise the success of this treatment in a substantial number of patients. We used...

  • The CD3-16+56+ NK cell count independently predicts autologous blood stem cell mobilization. Stewart, D A; Guo, D; Luider, J; Auer, I; Klassen, J; Morris, D; Brown, C B; Chaudhry, A; Glück, S; Russell, J A // Bone Marrow Transplantation;6/15/2001, Vol. 27 Issue 12, p1237 

    Better predictive factors for autologous blood stem cell mobilization (BSCM) are needed. The purpose of this study was to determine if an independent association exists between lymphocyte or NK cell counts and BSCM. Data were analyzed on 141 consecutive patients aged 19–69 years (median...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics