Impact of Obesity on Thyroid Function in Children

Elaiady, Ahmed Ali; Abdelwahab Elashmawy, Iman; Abdelmawgod Abdelmaksoud, Sohair; Megahed, Hala Salah; Farouk Mohamed, Mohamed; Mahmoud Elbarawy, Mohammed
March 2013
Journal of Applied Sciences Research;Mar2013, Vol. 9 Issue 3, p2026
Academic Journal
Background: Obesity is considered to be a worldwide health problem with a steadily and dramatically increasing prevalence all over the world. Obese individuals are, in fact, at high risk of developing dyslipidemia, hypertension and impaired glucose tolerance, with consequent increase of the risk of metabolic and cardiovascular diseases Objectives: The aim of the study is to determine the effect of obesity on thyroid profile in children. Subjects and Methods: A cross sectional study comprised 90 children, 50 obese children of both sexes with a BMI of more than 95th percentile for age and sex, and 40 children of both sexes between (15th percentile-85th percentile) for age and sex serving as controls. Their age ranged from 6 to 10 years old. All cases and controls were subjected to full history taking and thorough clinical examination. All children were subjected to analysis of serum T3, T4, TSH and thyroid antibodies. Results: Our results showed that the mean TSH concentration was significantly higher in obese group 6.58 ± 4.74 μIU/mL compared with control group 1.95 ± 1.86 μIU/mL. The mean T3 concentration was significantly higher in control group 1.43 ± 0.49 ng/mL compared with obese group 0.81 ± 0.54 ng/mL. The mean T4 concentration was significantly higher in control group 8.52 ± 3.72 μg/dL compared with obese group 4.38 ± 3.10 μg/dL. The mean T.V hours/day was significantly higher in obese group 4.32 ± 1.15 hour compared with control group 2.73 ± 1.01 hour. It was noted that there is a significant difference between control group and obese group as regards food quality especially the mean of soda bottles per week, 1.45 ± 1.09 bottles in control group and 3.34 ± 1.64 bottles in obese group. Conclusion: Obesity is associated with hypothyroidism, lack of breastfeeding, increase TV watching hours and unhealthy eating habits, although, further studies should be done to identify the effect of weight reduction on thyroid profile in obese children.


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