TITLE

CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation

AUTHOR(S)
Jones, C; Nonni, A V; Fulford, L; Merrett, S; Chaggar, R; Eusebi, V; Lakhani, S R
PUB. DATE
August 2001
SOURCE
British Journal of Cancer;8/1/2001, Vol. 85 Issue 3, p422
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
2-18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient.
ACCESSION #
8879208

 

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