TITLE

Anticancer drugs: Cracking the combination

AUTHOR(S)
Bordon, Yvonne
PUB. DATE
July 2013
SOURCE
Nature Reviews Drug Discovery;Jul2013, Vol. 12 Issue 7, p505
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article focuses on two studies published in the journals "Science" and "The Journal of Clinical Investigation" which examined new strategies for combining cancer immunotherapies. In one study, the CD47-binding domain of signal regulatory protein-α (SIRPα) was used as an antagonist for CD47. A mouse model of lymphoma was used to test the efficacy of SIRPα combined with tumour-specific antibodies. Another study found that CpG oligodeoxynucleotides have limited effect on tumors.
ACCESSION #
88783760

 

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